{"id":"W2811096106","doi":"10.1016/j.omtn.2018.05.023","title":"A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Aptamer; PEGylation; Chemistry; Immune system; In vivo; Agonist; Cell biology; Polyethylene glycol; Receptor; Biology; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386918,0.000319161,0.0001930559,0.0001381251,0.00006114829,0.0001405077,0.0001360502,0.000348024,0.00104878],"category_scores_gemma":[0.00009110309,0.000100046,0.000148494,0.0000976556,0.00009734887,0.00009076552,0.0001221802,0.0004349969,0.0003845662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617227,"about_ca_system_score_gemma":0.00009368451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009224618,"about_ca_topic_score_gemma":0.0002267187,"domain_scores_codex":[0.9998974,0.00001865329,0.000008280269,0.00002591567,0.00003010234,0.00001962602],"domain_scores_gemma":[0.9999447,0.00001021671,0.00001810908,0.000006689308,0.000005861735,0.00001440138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004159687,0.0000196955,0.00004707173,0.00001537051,0.000001993003,0.00001689771,0.000003224589,0.00006773204,0.9988559,0.0000198232,0.00001485638,0.0008958088],"study_design_scores_gemma":[0.00001363486,0.0004355222,0.0006014228,0.000002616871,0.000008417785,0.0001841782,0.00000517853,0.0005282005,0.9969356,0.00001516819,0.001267932,0.000002037434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915279,0.001233205,0.005295119,0.0000894875,0.00002006542,0.00004449467,0.0001857683,0.00008975407,0.001514092],"genre_scores_gemma":[0.9909821,0.0006183657,0.005509484,0.0001264086,0.000009196801,0.00004603152,0.0004120622,0.00001588898,0.002280343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104878,"threshold_uncertainty_score":0.003508508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009428480838944094,"score_gpt":0.2743936534346098,"score_spread":0.2649651725956657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}