{"id":"W2811096106","doi":"10.1016/j.omtn.2018.05.023","title":"A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Aptamer; PEGylation; Chemistry; Immune system; In vivo; Agonist; Cell biology; Polyethylene glycol; Receptor; Biology; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003988802,0.0003667957,0.0003359701,0.0001740143,0.0002041177,0.0001207768,0.0004585698,0.0003075422,0.00006566623],"category_scores_gemma":[0.0001596887,0.0003293724,0.0002469997,0.0002339007,0.0008991454,0.00001283206,0.0001701093,0.0001658213,0.00001812428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000399485,"about_ca_system_score_gemma":0.00007809601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002605927,"about_ca_topic_score_gemma":0.00005959582,"domain_scores_codex":[0.997901,0.0002234897,0.0004593478,0.0006714948,0.0002590927,0.0004856108],"domain_scores_gemma":[0.9985479,0.00002280812,0.0001527857,0.000991749,0.000197921,0.00008688024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007677064,0.0001044957,0.003700471,0.000008372604,0.00008685626,0.00005019746,0.0000784072,0.00000423073,0.9931129,0.00008766723,0.0002024952,0.001796231],"study_design_scores_gemma":[0.0006381387,0.0004676533,0.005498689,0.00003591173,0.00001242952,0.00003128211,0.00005233747,0.00001918928,0.9035813,0.0001759754,0.08909848,0.0003886336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950269,0.00156163,0.001187468,0.0002054233,0.00009483955,0.0002441411,0.00003191058,0.0001064737,0.001541214],"genre_scores_gemma":[0.9946248,0.0008796814,0.002006132,0.0005521656,0.0001861068,0.0000273474,0.0000324441,0.00007257699,0.001618726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08953159,"threshold_uncertainty_score":0.9999158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009428480838944094,"score_gpt":0.2743936534346098,"score_spread":0.2649651725956657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}