{"id":"W2811100276","doi":"10.1111/bph.14430","title":"Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease‐activated receptor 1‐ and protease‐activated receptor 4‐dependent mechanism","year":2018,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"H2020 European Research Council; Conseil Régional Midi-Pyrénées; Région Occitanie Pyrénées-Méditerranée; Bpifrance","keywords":"Thrombin; Organoid; Apoptosis; Cell biology; Biology; Thrombin receptor; Receptor; Cell growth; Chemistry; Cancer research; Immunology; Biochemistry; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727716,0.0002148924,0.0002126607,0.00024474,0.000130559,0.0002427688,0.00008461152,0.000215984,0.00158615],"category_scores_gemma":[0.0001727825,0.0001067063,0.0002460334,0.0001488056,0.0001962564,0.0001759949,0.0001398106,0.0004178107,0.0003275409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001884832,"about_ca_system_score_gemma":0.0001573084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006251974,"about_ca_topic_score_gemma":0.0006187332,"domain_scores_codex":[0.999861,0.00004606899,0.00001370604,0.00002237793,0.00003539178,0.00002145001],"domain_scores_gemma":[0.9998597,0.00005360505,0.00002970947,0.00001957103,0.00001928099,0.0000181303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005131022,0.00003254009,0.0004714374,0.0000814424,0.000007788261,0.0001374731,0.0000433612,0.00008359006,0.9964004,0.0000382705,0.00004589422,0.002144731],"study_design_scores_gemma":[0.00004459143,0.001986447,0.0150868,0.00001281258,0.00005355138,0.000984206,0.0001163781,0.0007992677,0.9772156,0.00007301269,0.003618202,0.000009187274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851823,0.008613227,0.003652412,0.0001385965,0.0000444397,0.00004761204,0.0004284982,0.00004309856,0.001849856],"genre_scores_gemma":[0.9932494,0.003021609,0.001948547,0.00004450672,0.00001057572,0.00004575336,0.0003872088,0.000008026623,0.001284412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00158615,"threshold_uncertainty_score":0.005306184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211664628022988,"score_gpt":0.2913846757163533,"score_spread":0.2702182129140545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}