{"id":"W2811149247","doi":"10.1016/j.jcmgh.2018.06.008","title":"IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model","year":2018,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Bristol-Myers Squibb Canada; National Institutes of Health","keywords":"Organoid; Interleukin 22; Progenitor cell; Stem cell; Biology; Cell biology; Regeneration (biology); Cytokine; Immunology; Interleukin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002277224,0.0004467027,0.0002916355,0.0005035827,0.0001480146,0.0003069572,0.0002375811,0.0003487899,0.001770899],"category_scores_gemma":[0.0001130517,0.0001204335,0.0003083081,0.0001739064,0.0003258792,0.000205097,0.0002144422,0.001035343,0.0004231583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519711,"about_ca_system_score_gemma":0.0002719608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587573,"about_ca_topic_score_gemma":0.0006136888,"domain_scores_codex":[0.9998363,0.00004025543,0.00001403474,0.00002616929,0.00004719667,0.00003601158],"domain_scores_gemma":[0.9997637,0.00003816384,0.00005697931,0.00003115579,0.00001844212,0.00009161912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004611463,0.0003190515,0.0001693902,0.00005943492,0.000006601544,0.0000846933,0.00003183404,0.0002116282,0.9967119,0.00009944595,0.0001046616,0.001740302],"study_design_scores_gemma":[0.00005408354,0.002082579,0.001056858,0.00001231794,0.00002250526,0.0001162748,0.00003650607,0.001095044,0.9933304,0.00003958107,0.002149356,0.000004359189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993018,0.001186372,0.002724304,0.0001520605,0.00008236671,0.00006923594,0.000368737,0.0001679933,0.002230844],"genre_scores_gemma":[0.9920243,0.0008539773,0.002314808,0.00007124936,0.00001816433,0.0001242331,0.0005404048,0.00002670244,0.004026061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770899,"threshold_uncertainty_score":0.005924284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005987812662925134,"score_gpt":0.2104630583419138,"score_spread":0.2044752456789886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}