{"id":"W2811170565","doi":"10.6000/1929-2279.2018.07.03.2","title":"Early Phase I Results for 4-Demethyl-4-cholesteryloxypenclo-medine [DM-CHOC-PEN] as Therapy in Adolescent and Young Adult (AYA) Subjects with Advanced Malignancies","year":2018,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Clinical trial; Pharmacokinetics; Oncology; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122253,0.0001924703,0.0002834576,0.0002088717,0.0001318115,0.00009882782,0.0003035241,0.0001113832,0.00001181696],"category_scores_gemma":[0.0001510596,0.0001424674,0.00006517145,0.0002301116,0.0002634824,0.00003334028,0.00007290381,0.0002905521,0.000001186555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008292511,"about_ca_system_score_gemma":0.0004609447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002206898,"about_ca_topic_score_gemma":0.001012379,"domain_scores_codex":[0.9981062,0.0001025029,0.000420473,0.0003476703,0.0005081081,0.0005150301],"domain_scores_gemma":[0.9977757,0.00003948036,0.0002461917,0.0002574907,0.001493643,0.0001874981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02014996,0.0001914031,0.001076943,0.00003557197,0.0001201132,0.00001995873,0.0004540508,0.000005708998,0.9253147,0.00007614945,0.0008751894,0.05168024],"study_design_scores_gemma":[0.01361595,0.01378886,0.002451517,0.0003711176,0.00001747834,0.00004796372,0.0004017155,0.00002082395,0.9341081,0.0004847543,0.03447046,0.0002212249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920338,0.005629957,0.0002142235,0.001155629,0.0002406197,0.000539087,0.00006730251,0.000003642594,0.0001157512],"genre_scores_gemma":[0.9796749,0.01804105,0.0007632991,0.000390704,0.0007173634,0.00007386781,0.00001438364,0.00003840243,0.0002859745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05145901,"threshold_uncertainty_score":0.580965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04244944845397382,"score_gpt":0.3989724035403185,"score_spread":0.3565229550863447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}