{"id":"W2811170565","doi":"10.6000/1929-2279.2018.07.03.2","title":"Early Phase I Results for 4-Demethyl-4-cholesteryloxypenclo-medine [DM-CHOC-PEN] as Therapy in Adolescent and Young Adult (AYA) Subjects with Advanced Malignancies","year":2018,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Clinical trial; Pharmacokinetics; Oncology; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005932251,0.0004598329,0.0005423581,0.0001833655,0.0002863764,0.0003677536,0.0003139467,0.0005599121,0.001774472],"category_scores_gemma":[0.0003907381,0.0001372103,0.0003761004,0.0001560875,0.0002873024,0.0002568031,0.0001609322,0.001012809,0.0003287453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002909767,"about_ca_system_score_gemma":0.0004745271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005788741,"about_ca_topic_score_gemma":0.001835419,"domain_scores_codex":[0.9998554,0.00006360742,0.000008976258,0.00002114433,0.00001648749,0.00003442943],"domain_scores_gemma":[0.9995883,0.00007766543,0.00006353199,0.0000224186,0.00004104998,0.0002071244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2247534,0.08311117,0.04213843,0.0009913634,0.0009851352,0.00116683,0.001147177,0.00261992,0.367112,0.0004676394,0.004649459,0.2708575],"study_design_scores_gemma":[0.04489936,0.8371091,0.0661414,0.00006077478,0.0003551928,0.001181514,0.0001687359,0.001171943,0.0418471,0.0001409997,0.006898714,0.00002516863],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973481,0.0009108741,0.0002203464,0.00009462098,0.00001785842,0.0003351778,0.0002819026,0.00002285694,0.0007683317],"genre_scores_gemma":[0.9951845,0.0008125448,0.001153242,0.0002506132,0.00003332925,0.0003906011,0.0007898249,0.00001033952,0.001375131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774472,"threshold_uncertainty_score":0.005936146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04244944845397382,"score_gpt":0.3989724035403185,"score_spread":0.3565229550863447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}