{"id":"W2811212478","doi":"10.1016/j.ibror.2018.06.001","title":"The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition","year":2018,"lang":"en","type":"article","venue":"IBRO Reports","topic":"Birth, Development, and Health","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba; Research Manitoba","keywords":"Subfornical organ; Overnutrition; Transcriptome; Endocrinology; Internal medicine; Biology; Circumventricular organs; Leptin; Ghrelin; Glucose homeostasis; Microarray analysis techniques; Energy homeostasis; Gene expression; Hormone; Hypothalamus; Gene; Diabetes mellitus; Medicine; Genetics; Angiotensin II; Obesity; Insulin resistance; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009289999,0.00009582722,0.0001962788,0.0000642021,0.0001167258,0.00001378159,0.00008342609,0.00008888699,0.00006334083],"category_scores_gemma":[0.0002863508,0.00005632504,0.00006831633,0.0002954876,0.0001233829,0.00004512708,0.00003090566,0.0001755092,0.00001410829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009437592,"about_ca_system_score_gemma":0.000407682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002105212,"about_ca_topic_score_gemma":0.0001987024,"domain_scores_codex":[0.9985194,0.00009740157,0.0005339551,0.0002216494,0.0003783666,0.0002492878],"domain_scores_gemma":[0.9990508,0.00006596149,0.0001409703,0.0004856562,0.0001312204,0.0001254022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01148852,0.0003966533,0.4064363,0.0001937316,0.00006325978,0.0008791749,0.01426185,1.036189e-7,0.5391682,0.001099947,0.02466546,0.001346735],"study_design_scores_gemma":[0.0007157313,0.0004373016,0.9498981,0.000192183,0.00001227841,0.0006481283,0.0001305752,0.000001609812,0.03909817,0.001259905,0.007533046,0.00007299196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871952,0.00008963516,0.000007567765,0.01082016,0.0005638719,0.0005419443,0.000006480434,0.00001840996,0.0007567049],"genre_scores_gemma":[0.9974539,0.0002243575,0.0001102746,0.001694404,0.0001469897,0.00001232198,0.000003173841,0.00001518529,0.0003394301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5434618,"threshold_uncertainty_score":0.2296869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998858801208777,"score_gpt":0.2995291792501472,"score_spread":0.2795405912380594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}