{"id":"W2811214182","doi":"10.1097/coc.0000000000000474","title":"Dynamic Angiogenic Switch as Predictor of Response to Chemotherapy-Bevacizumab in Patients With Metastatic Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Bevacizumab; Irinotecan; Internal medicine; Capecitabine; Oncology; Colorectal cancer; Oxaliplatin; Chemotherapy; Progression-free survival; Vascular endothelial growth factor; Gastroenterology; Placental growth factor; Surgery; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004654546,0.0001806028,0.0002583294,0.0003171717,0.0001834239,0.0003191321,0.0001497086,0.0003323079,0.0007302706],"category_scores_gemma":[0.001732233,0.00008793563,0.0001804764,0.0004136231,0.0001648629,0.0002158379,0.0001712927,0.0004650166,0.0001100739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786833,"about_ca_system_score_gemma":0.0002121567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004761522,"about_ca_topic_score_gemma":0.0006259466,"domain_scores_codex":[0.9997916,0.0000636921,0.00002250731,0.00003762327,0.00004678497,0.00003781507],"domain_scores_gemma":[0.9987763,0.0003602216,0.0005578162,0.00002447578,0.00008545315,0.0001957576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001338656,0.00006520496,0.9937452,0.00001503726,0.0000313559,0.000100221,0.00002394067,0.0001558465,0.001000038,0.00001199391,0.00007201545,0.003440352],"study_design_scores_gemma":[0.00004805338,0.0008092846,0.9968541,0.000005379724,0.00004673577,0.0005991831,0.00003893426,0.0008909851,0.0003406104,0.00003223804,0.0003303786,0.000004053543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992193,0.0003889817,0.00006887459,0.00003715448,0.000004382649,0.000007935498,0.00007494268,0.000002314073,0.0001961211],"genre_scores_gemma":[0.9996463,0.00006469755,0.0000794705,0.00001428723,0.00001187706,0.000008459248,0.000120647,5.951634e-7,0.00005357797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007302706,"threshold_uncertainty_score":0.002461553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270515441973878,"score_gpt":0.4152128563473981,"score_spread":0.3925077019276593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}