{"id":"W2811224532","doi":"10.1101/358531","title":"Gene activation precedes DNA demethylation in response to infection in human dendritic cells","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Fonds de Recherche du Québec - Santé; Compute Canada","keywords":"DNA methylation; DNA demethylation; Biology; Epigenetics; Epigenetics of physical exercise; Methylation; Epigenomics; Demethylation; Enhancer; Chromatin; DNA; Regulation of gene expression; Gene expression; Gene; Transcription (linguistics); Innate immune system; CpG site; Promoter; Molecular biology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496104,0.0001078217,0.0001910159,0.0002781662,0.0001249153,0.000230786,0.0001017839,0.0001753962,0.001636328],"category_scores_gemma":[0.000197751,0.000117685,0.0001559239,0.0001951407,0.0001321499,0.00007829112,0.0001624298,0.000327158,0.0004826081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214162,"about_ca_system_score_gemma":0.0001174265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006424662,"about_ca_topic_score_gemma":0.0006509496,"domain_scores_codex":[0.9999011,0.00001063001,0.000006492121,0.00003493112,0.00001895564,0.00002793037],"domain_scores_gemma":[0.9998773,0.00003057152,0.00002201791,0.00001964741,0.00002310734,0.0000273005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409829,0.00001156663,0.001703663,0.00002012256,0.000004308914,0.0000382459,0.00002326746,0.00002989205,0.9969485,0.00003528533,0.0000322253,0.0009119383],"study_design_scores_gemma":[0.0000210045,0.0001611108,0.0703658,0.000004658691,0.00001054844,0.0002117394,0.0000619828,0.0006159372,0.926356,0.000109086,0.002077687,0.000004426377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936917,0.001588547,0.00203013,0.00007421893,0.00001877705,0.0000237967,0.001381628,0.00004046644,0.001150648],"genre_scores_gemma":[0.996123,0.000374827,0.0009367543,0.00003829044,0.000009305003,0.0000233533,0.001208797,0.000008835774,0.001276833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636328,"threshold_uncertainty_score":0.005474031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01457790976604613,"score_gpt":0.2571290448336321,"score_spread":0.242551135067586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}