{"id":"W2811278130","doi":"10.1007/s11426-018-9283-3","title":"A new class of HIV-1 inhibitors and the target identification via proteomic profiling","year":2018,"lang":"en","type":"article","venue":"Science China Chemistry","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Docking (animal); Drug discovery; Human immunodeficiency virus (HIV); Chemistry; Computational biology; Combinatorial chemistry; Protein subunit; Biology; Biochemistry; Virology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948637,0.0006927493,0.0004290266,0.0006551316,0.0003083469,0.0006320495,0.0003452823,0.0003418268,0.001088519],"category_scores_gemma":[0.0001320134,0.0002191529,0.000336493,0.0004735597,0.0001845558,0.0004989121,0.0002572119,0.0009073088,0.0007094773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003893518,"about_ca_system_score_gemma":0.0003470645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004289802,"about_ca_topic_score_gemma":0.0008631755,"domain_scores_codex":[0.9998987,0.000009622328,0.000005956576,0.00002367581,0.00004347785,0.00001857804],"domain_scores_gemma":[0.9999568,0.000005036513,0.000007630712,0.000004933675,0.00001523296,0.0000102661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994749,0.0001376589,0.0003682541,0.0001620951,0.00003328027,0.0001189429,0.00001745136,0.0002415454,0.9621953,0.0007874983,0.0007755207,0.03496302],"study_design_scores_gemma":[0.00006157585,0.0006050317,0.003006801,0.00002129923,0.0001193111,0.0009311332,0.00002381548,0.002784447,0.9611049,0.0004039519,0.03091279,0.00002509512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7570155,0.1135217,0.08926173,0.001942738,0.0006355211,0.001161461,0.004761649,0.001164619,0.03053512],"genre_scores_gemma":[0.8551461,0.05638879,0.06028762,0.001198233,0.0002402267,0.0007702033,0.004684557,0.00008639637,0.02119792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088519,"threshold_uncertainty_score":0.003641486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005598534886301122,"score_gpt":0.2325078502340363,"score_spread":0.2269093153477351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}