{"id":"W2811292509","doi":"10.1101/359117","title":"<i>Salmonella</i> effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan; Canadian Light Source","keywords":"TRADD; Death domain; Effector; Immunoprecipitation; Cell biology; Glycosyltransferase; Biology; Secretion; Arginine; Type three secretion system; Signal transduction; FADD; Ectopic expression; Receptor; Biochemistry; Chemistry; Enzyme; Amino acid; Virulence; Programmed cell death; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627463,0.0004165656,0.0001849808,0.0001754007,0.0001534975,0.0003727471,0.0001786371,0.0002897539,0.001942091],"category_scores_gemma":[0.00007993015,0.0001296309,0.0003017701,0.0001330464,0.0002824398,0.0001647272,0.0002344591,0.0005169447,0.0009963315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004832105,"about_ca_system_score_gemma":0.0001901569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003875528,"about_ca_topic_score_gemma":0.0005511979,"domain_scores_codex":[0.9998536,0.00002364593,0.00001560466,0.00002979361,0.00004281664,0.00003448863],"domain_scores_gemma":[0.9999052,0.000007715876,0.00003993805,0.00001299911,0.00001080165,0.00002327126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008386847,0.00001423986,0.000292044,0.00001726955,0.000003287186,0.0000225136,0.000004420099,0.00003744961,0.9986793,0.000120778,0.00006754765,0.0006571414],"study_design_scores_gemma":[0.00001109871,0.0001253557,0.003815094,0.000003835426,0.000007951448,0.0003056212,0.00001760605,0.0006157616,0.9925563,0.00005232364,0.002486375,0.000002710258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864246,0.001097312,0.007461952,0.0003115273,0.00006685923,0.00004532278,0.0009967537,0.0003100577,0.00328563],"genre_scores_gemma":[0.9814238,0.0005486778,0.009465878,0.0001310436,0.00001428612,0.00004352574,0.002481849,0.00005893348,0.005831942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942091,"threshold_uncertainty_score":0.006496966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178606389819992,"score_gpt":0.2073242060371205,"score_spread":0.1855381421389206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}