{"id":"W2811329358","doi":"10.1194/jlr.m084442","title":"Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration","year":2018,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Starr Foundation; National Heart, Lung, and Blood Institute; Glenn Foundation for Medical Research; National Eye Institute; VitreoRetinal Surgery Foundation; Research to Prevent Blindness; Carl Marshall and Mildred Almen Reeves Foundation; National Institutes of Health; Edward N. and Della L. Thome Memorial Foundation; International Retinal Research Foundation","keywords":"Neurodegeneration; Retina; ABCA1; Lipid metabolism; Cell biology; Biology; Retinal degeneration; Visual phototransduction; Cholesterol; Photoreceptor cell; Neuroscience; Biochemistry; Internal medicine; Transporter; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135686,0.0003465963,0.0003951777,0.0006183105,0.0003290194,0.0005092761,0.0001809805,0.0006372262,0.002272495],"category_scores_gemma":[0.0001763292,0.000143476,0.0002874095,0.0002570915,0.0002100717,0.000244797,0.0004079333,0.0006276162,0.0007385975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006637599,"about_ca_system_score_gemma":0.0003467883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002086862,"about_ca_topic_score_gemma":0.00247457,"domain_scores_codex":[0.9997705,0.00002825198,0.00001906725,0.00004899624,0.00007565469,0.0000575819],"domain_scores_gemma":[0.9998286,0.00001099425,0.00005400669,0.00001376935,0.00004325441,0.00004941336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005702745,0.0001317604,0.003206455,0.0001381285,0.00003698624,0.0004828253,0.00003313839,0.00007446743,0.9863941,0.0003232498,0.001106468,0.007502114],"study_design_scores_gemma":[0.0001417493,0.001314093,0.2109497,0.0001768412,0.000266915,0.005829221,0.0002945882,0.002194011,0.7504686,0.001193758,0.02710992,0.000060665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667215,0.02297013,0.002481672,0.001476595,0.0002737332,0.00004208457,0.001275229,0.0003413383,0.004417683],"genre_scores_gemma":[0.9843461,0.007466955,0.001015953,0.0002880885,0.00005955392,0.00004145735,0.0004451593,0.00002675514,0.006309954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272495,"threshold_uncertainty_score":0.007602215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435214823190994,"score_gpt":0.3469757303068849,"score_spread":0.312623582074975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}