{"id":"W2811329358","doi":"10.1194/jlr.m084442","title":"Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration","year":2018,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Starr Foundation; National Heart, Lung, and Blood Institute; Glenn Foundation for Medical Research; National Eye Institute; VitreoRetinal Surgery Foundation; Research to Prevent Blindness; Carl Marshall and Mildred Almen Reeves Foundation; National Institutes of Health; Edward N. and Della L. Thome Memorial Foundation; International Retinal Research Foundation","keywords":"Neurodegeneration; Retina; ABCA1; Lipid metabolism; Cell biology; Biology; Retinal degeneration; Visual phototransduction; Cholesterol; Photoreceptor cell; Neuroscience; Biochemistry; Internal medicine; Transporter; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207496,0.0001055168,0.0001490854,0.0001823367,0.0001520621,0.00008194559,0.000281857,0.0001217863,0.0001285192],"category_scores_gemma":[0.0004262135,0.00008090887,0.00009266802,0.0002552593,0.0002386283,0.00001383852,0.00009489121,0.0002789516,0.00003941235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001351947,"about_ca_system_score_gemma":0.0001698552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004908686,"about_ca_topic_score_gemma":0.000009287402,"domain_scores_codex":[0.9983871,0.0002826072,0.0003649586,0.0001798477,0.0005039332,0.000281563],"domain_scores_gemma":[0.9987578,0.00001792617,0.0001406422,0.0001663299,0.0007861951,0.0001310468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002373538,0.00008791398,0.001876559,0.000008943189,0.00005827309,0.000006477009,0.0001853384,0.000002926065,0.978681,0.00002794371,0.01575605,0.003071232],"study_design_scores_gemma":[0.00120154,0.001222822,0.02208062,0.00003235806,0.00001346902,0.00006561721,0.0001121837,0.0000556995,0.7990512,0.0001489323,0.1758562,0.0001593796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958638,0.0003213516,0.0001195212,0.0008189538,0.0005856178,0.0001531256,0.000001606707,0.000004012888,0.002132036],"genre_scores_gemma":[0.9955272,0.0002759772,0.000543987,0.00007934429,0.001472153,0.000004960338,0.00001861188,0.00002002967,0.002057744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1796298,"threshold_uncertainty_score":0.3299368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435214823190994,"score_gpt":0.3469757303068849,"score_spread":0.312623582074975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}