{"id":"W2811334205","doi":"10.1002/cbic.201800255","title":"A Bioluminescent Ca<sup>2+</sup> Indicator Based on a Topological Variant of GCaMP6s","year":2018,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Bioluminescence; Optogenetics; Fluorescence; Chemistry; Luciferase; Biophysics; Förster resonance energy transfer; Channelrhodopsin; Biochemistry; Physics; Biology; Neuroscience; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907532,0.0005136046,0.0002972965,0.0002697712,0.0001783895,0.00063016,0.0007267167,0.0005443565,0.0007603333],"category_scores_gemma":[0.0003770275,0.0001911005,0.0002009087,0.0002588772,0.0008458558,0.0005228651,0.0003846954,0.0007517518,0.000521074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007717502,"about_ca_system_score_gemma":0.0003384649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004581679,"about_ca_topic_score_gemma":0.0004997751,"domain_scores_codex":[0.9998404,0.00002181012,0.00001298443,0.00004755851,0.00005206302,0.00002511035],"domain_scores_gemma":[0.9997485,0.00004148664,0.00007885261,0.00002330219,0.00004268828,0.00006507074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002781915,0.000004371466,0.00006545612,0.00002952163,0.000002158581,0.00002875235,0.000006165943,0.000103577,0.9985592,0.0004107502,0.00005072863,0.0007115404],"study_design_scores_gemma":[0.000004259905,0.00003607274,0.0002123617,0.000002487737,0.000003543612,0.0001119047,0.00000547137,0.0006424203,0.9976355,0.00003044514,0.001310868,0.000004621755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929193,0.001708165,0.06039109,0.0008873597,0.0001824223,0.000128094,0.0008066168,0.000997751,0.005705613],"genre_scores_gemma":[0.9468037,0.0009018378,0.04707197,0.0001789194,0.00001956554,0.0000899555,0.0006336719,0.0001216847,0.004178754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007717502,"threshold_uncertainty_score":0.005599439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04468605788872072,"score_gpt":0.3131766872986982,"score_spread":0.2684906294099775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}