{"id":"W2811401701","doi":"10.1158/1538-7445.am2018-819","title":"Abstract 819: High response rates with entospletinib in patients with t(v;11q23.3);<i>KMT2A</i> rearranged acute myeloid leukemia and acute lymphoblastic leukemia","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cytarabine; Myeloid leukemia; Leukemia; Acute leukemia; Chemotherapy; Internal medicine; Gastroenterology; Induction chemotherapy; Myeloid; Acute lymphocytic leukemia; Vincristine; Oncology; Immunology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005457914,0.0002805208,0.0007706731,0.0001470639,0.0001795983,0.0004890253,0.0002028794,0.0003500396,0.002123623],"category_scores_gemma":[0.000444911,0.0001107473,0.0004068232,0.0002596633,0.0001364903,0.0002388977,0.0001520884,0.0005622397,0.000405738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667533,"about_ca_system_score_gemma":0.0003897164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003198342,"about_ca_topic_score_gemma":0.001263218,"domain_scores_codex":[0.999775,0.00007565734,0.00002483638,0.00006241198,0.00002951484,0.00003259166],"domain_scores_gemma":[0.9997395,0.00006828756,0.00006058003,0.00001858976,0.00002156482,0.00009148148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2795841,0.007377445,0.2572318,0.001255031,0.001699369,0.001551811,0.0003394336,0.002801781,0.1277811,0.0002875662,0.01086632,0.3092242],"study_design_scores_gemma":[0.06069495,0.1166941,0.7632412,0.0001284273,0.002047988,0.004925306,0.0002755978,0.003327727,0.02849499,0.0002946712,0.0198043,0.00007075878],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964774,0.00116369,0.0001144269,0.0001526117,0.00002417941,0.0001376831,0.0007625225,0.00001699862,0.001150463],"genre_scores_gemma":[0.9975638,0.0003690136,0.0001541672,0.0001174283,0.00003006757,0.00007479391,0.001221044,0.000004978214,0.0004647307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123623,"threshold_uncertainty_score":0.007104218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137495479313491,"score_gpt":0.3333395373591177,"score_spread":0.3119645825659828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}