{"id":"W2811415192","doi":"10.1017/cjn.2018.94","title":"B.06 Safety and efficacy of nusinersen in infants/children with spinal muscular atrophy (SMA): part 1 of the phase 2 EMBRACE study","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Tolerability; Milestone; SMA*; Spinal muscular atrophy; Medicine; Adverse effect; Pediatrics; Clinical endpoint; Randomized controlled trial; Surgery; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002803858,0.0002268467,0.0005601171,0.0006833292,0.0008260677,0.00009704604,0.001062018,0.00008991288,0.0000565168],"category_scores_gemma":[0.001468666,0.0001198022,0.0001596262,0.001717935,0.01057113,0.0002523382,0.00009695561,0.0008020623,3.782902e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005739754,"about_ca_system_score_gemma":0.002707019,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001894535,"about_ca_topic_score_gemma":0.03161747,"domain_scores_codex":[0.9961858,0.0008718511,0.0008069022,0.0004201088,0.0009537796,0.0007615456],"domain_scores_gemma":[0.9976466,0.0001825426,0.0005948333,0.0002222432,0.0004662326,0.0008875519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006740788,0.0001950062,0.9934359,0.000007729855,0.00003196149,0.0008597653,0.0003990709,0.0003006554,0.0001457527,0.00005514448,0.00003692336,0.00385797],"study_design_scores_gemma":[0.002144235,0.1110871,0.8777003,0.00007345434,0.00007512241,0.007554321,0.0003909332,0.0001996685,0.000145764,0.0001879924,0.0003242307,0.0001168133],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966134,0.0007245752,0.00000841488,0.001639631,0.0001432245,0.0004672595,0.000006559909,0.000003119377,0.0003937737],"genre_scores_gemma":[0.998825,0.0001960099,0.0003118285,0.0005332545,0.0001142359,0.000001194418,1.170427e-7,0.000008505432,0.00000991164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1157356,"threshold_uncertainty_score":0.9921215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02758403866507589,"score_gpt":0.3101311937362786,"score_spread":0.2825471550712026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}