{"id":"W2811415192","doi":"10.1017/cjn.2018.94","title":"B.06 Safety and efficacy of nusinersen in infants/children with spinal muscular atrophy (SMA): part 1 of the phase 2 EMBRACE study","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Tolerability; Milestone; SMA*; Spinal muscular atrophy; Medicine; Adverse effect; Pediatrics; Clinical endpoint; Randomized controlled trial; Surgery; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002799191,0.0008729006,0.001198692,0.0002433391,0.0003565256,0.0007071074,0.0007505486,0.001839536,0.01102463],"category_scores_gemma":[0.001783858,0.0004155292,0.001104654,0.0001744871,0.0005753398,0.000755258,0.0004052621,0.0018197,0.001715872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004834051,"about_ca_system_score_gemma":0.001040211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005911655,"about_ca_topic_score_gemma":0.001975776,"domain_scores_codex":[0.99928,0.0004270872,0.00004099007,0.00007944814,0.00009381297,0.00007863239],"domain_scores_gemma":[0.999044,0.0002293939,0.0002320876,0.00009336317,0.0001406693,0.0002604627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8400185,0.02109974,0.005981558,0.003431842,0.001705088,0.0003057191,0.000324516,0.0009579843,0.03877749,0.0006234739,0.01021183,0.07656244],"study_design_scores_gemma":[0.6210846,0.3441613,0.01736783,0.0003093961,0.0005891508,0.0005083543,0.00009542573,0.0006145582,0.005215355,0.0002810488,0.009728667,0.00004433411],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674653,0.007749459,0.0009914696,0.001324719,0.0002494103,0.006711205,0.007581849,0.0002369728,0.007689519],"genre_scores_gemma":[0.9649588,0.003543921,0.004225195,0.002509714,0.0002856712,0.007979635,0.00836718,0.00006591086,0.00806405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102463,"threshold_uncertainty_score":0.03688103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02758403866507589,"score_gpt":0.3101311937362786,"score_spread":0.2825471550712026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}