{"id":"W2811448442","doi":"10.1039/c8ra03535k","title":"Rational design, preparation and characterization of recombinant Ag85B variants and their glycoconjugates with T-cell antigenic activity against<i>Mycobacterium tuberculosis</i>","year":2018,"lang":"en","type":"article","venue":"RSC Advances","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Università degli Studi dell'Insubria; Fondazione del Monte di Bologna e Ravenna","keywords":"Glycoconjugate; Recombinant DNA; Antigen; Rational design; Chemistry; Tuberculosis; Mycobacterium tuberculosis; Biochemistry; Microbiology; Biology; Immunology; Medicine; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077425,0.0002512316,0.0001945098,0.0001051918,0.0000948097,0.0002535999,0.0002288512,0.0002090696,0.0002180723],"category_scores_gemma":[0.0002577411,0.00009538735,0.0001902362,0.0002056281,0.0001777904,0.0001583145,0.0001391606,0.000392906,0.0001862307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271005,"about_ca_system_score_gemma":0.0002477444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498449,"about_ca_topic_score_gemma":0.0005611588,"domain_scores_codex":[0.9998726,0.00003410734,0.0000115226,0.00001970205,0.00004264914,0.00001934116],"domain_scores_gemma":[0.9999343,0.000007668606,0.00002493813,0.00001053568,0.000011716,0.00001085745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007694076,0.00004690583,0.0002915135,0.00006683455,0.00001298403,0.00008851083,0.00002315187,0.001078161,0.9924436,0.0004553311,0.00006536632,0.005350737],"study_design_scores_gemma":[0.00002181266,0.0003394137,0.001306756,0.000006653705,0.00002511197,0.0002744624,0.00002096691,0.001956016,0.9897767,0.0001082308,0.006157721,0.000006093961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764923,0.002135062,0.01943672,0.0001426388,0.00003047461,0.0001513321,0.0003149042,0.00006314346,0.001233417],"genre_scores_gemma":[0.965123,0.001616025,0.03129026,0.00005383836,0.000007782536,0.00005029896,0.0008021147,0.00002807473,0.001028581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004498449,"threshold_uncertainty_score":0.001966298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009233847309922747,"score_gpt":0.2504792384642233,"score_spread":0.2412453911543005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}