{"id":"W2811452478","doi":"10.1093/toxsci/kfy171","title":"Preadolescent Phthalate (DEHP) Exposure Is Associated With Elevated Locomotor Activity and Reward-Related Behavior and a Reduced Number of Tyrosine Hydroxylase Positive Neurons in Post-Adolescent Male and Female Rats","year":2018,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tyrosine hydroxylase; Locomotor activity; Phthalate; Endocrinology; Internal medicine; Tyrosine; Chemistry; Enzyme assay; Dopamine; Biology; Psychology; Enzyme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018812,0.0002075487,0.0003043976,0.000032636,0.0002076199,0.00004784379,0.0001469506,0.0001157498,0.0002885963],"category_scores_gemma":[0.0001755526,0.0001339197,0.00002601798,0.0003816086,0.002228009,0.0001943385,0.0002693835,0.0001992305,0.000005023248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005588899,"about_ca_system_score_gemma":0.0000153006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002451581,"about_ca_topic_score_gemma":0.0001001944,"domain_scores_codex":[0.99832,0.0001685587,0.0002254028,0.0006026159,0.0002833497,0.0004000197],"domain_scores_gemma":[0.9993584,0.0001555443,0.0001681949,0.0001124505,0.00002364082,0.0001817772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001068797,0.0005542331,0.4496609,0.000006933592,0.000006164295,0.00004373582,0.0002313445,0.000003598743,0.5483349,0.000004076242,0.00001218102,0.001035112],"study_design_scores_gemma":[0.0006671417,0.001468887,0.8503232,0.0001066687,0.00002867596,0.0000884007,0.00005562061,0.0003105341,0.146747,0.00002408601,0.000001933504,0.0001778658],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984981,0.00003441876,5.352528e-7,0.000362238,0.00002246209,0.0005730006,0.00002604895,0.00002843965,0.0004546907],"genre_scores_gemma":[0.9995652,0.00003308648,0.0001401341,0.00011851,0.000007763928,0.00001596542,0.000002349388,0.000007368967,0.0001096293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4015879,"threshold_uncertainty_score":0.8209192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585700473648626,"score_gpt":0.3155594120360484,"score_spread":0.2997024072995622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}