{"id":"W2811452478","doi":"10.1093/toxsci/kfy171","title":"Preadolescent Phthalate (DEHP) Exposure Is Associated With Elevated Locomotor Activity and Reward-Related Behavior and a Reduced Number of Tyrosine Hydroxylase Positive Neurons in Post-Adolescent Male and Female Rats","year":2018,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tyrosine hydroxylase; Locomotor activity; Phthalate; Endocrinology; Internal medicine; Tyrosine; Chemistry; Enzyme assay; Dopamine; Biology; Psychology; Enzyme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008224479,0.0004583992,0.0003487464,0.0004369927,0.0001826065,0.000260277,0.0001856772,0.0003151465,0.002293761],"category_scores_gemma":[0.0001214828,0.0002910513,0.000269684,0.0001597676,0.0003570542,0.000243058,0.0002260401,0.00130656,0.0002266461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003157149,"about_ca_system_score_gemma":0.0004041408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003947,"about_ca_topic_score_gemma":0.005631392,"domain_scores_codex":[0.9998461,0.00000979415,0.00001023463,0.00004899458,0.00004819172,0.00003672598],"domain_scores_gemma":[0.9997029,0.00001415181,0.0001193722,0.00001475799,0.00003129557,0.0001174479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005723971,0.0002053347,0.002374905,0.00005015457,0.00001155708,0.000169756,0.00006341722,0.00002656545,0.994325,0.00005990455,0.00006868439,0.002072284],"study_design_scores_gemma":[0.00005255026,0.003926226,0.1953087,0.00002691584,0.00004722157,0.0007795665,0.0002845607,0.0002709081,0.797221,0.00009746891,0.001966805,0.00001814973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975559,0.0004719349,0.0004859088,0.00009523664,0.00002050523,0.00002061629,0.0006707637,0.00003445823,0.0006446778],"genre_scores_gemma":[0.986895,0.001407629,0.001350918,0.0001463023,0.00001511539,0.0001191206,0.001093127,0.00002525683,0.00894767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002293761,"threshold_uncertainty_score":0.007673383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585700473648626,"score_gpt":0.3155594120360484,"score_spread":0.2997024072995622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}