{"id":"W2811478179","doi":"10.1261/rna.067033.118","title":"Queuosine modification protects cognate tRNAs against ribonuclease cleavage","year":2018,"lang":"en","type":"article","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Congressionally Directed Medical Research Programs; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; U.S. Department of Defense","keywords":"Transfer RNA; Biology; Ribonuclease; RNA; Wobble base pair; Cleavage (geology); Translation (biology); Protein biosynthesis; Biochemistry; Cell biology; Translational regulation; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227689,0.0002324979,0.0002001544,0.0001357192,0.0001141963,0.0002694463,0.000134074,0.0002204779,0.0006809482],"category_scores_gemma":[0.0001818686,0.0000997696,0.0002021177,0.00007599623,0.0001674229,0.0001370741,0.0001720724,0.000275271,0.0002332306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000122737,"about_ca_system_score_gemma":0.0001411664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003177747,"about_ca_topic_score_gemma":0.000432643,"domain_scores_codex":[0.9998975,0.0000270935,0.0000121417,0.00002700303,0.00001983592,0.00001648968],"domain_scores_gemma":[0.9998562,0.00003726382,0.00004026245,0.00002821574,0.00001790782,0.00002004149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003495929,0.000003636725,0.0001457207,0.00000672378,0.00000228421,0.00002089062,0.000004400547,0.00001445592,0.9992874,0.00003266638,0.000005808854,0.0004411661],"study_design_scores_gemma":[0.000005151019,0.0001734117,0.00379382,0.000002788413,0.000008655291,0.0001857939,0.00001040368,0.0002302343,0.9941572,0.00003516463,0.001394636,0.000002745819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932313,0.001561869,0.003833625,0.00005507499,0.0000217404,0.0000145084,0.0001591823,0.00005650206,0.001066208],"genre_scores_gemma":[0.9966425,0.0004251262,0.001499132,0.00003949275,0.000006766214,0.000007849216,0.0003135103,0.00001291173,0.00105274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006809482,"threshold_uncertainty_score":0.00227803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637326257104231,"score_gpt":0.27281911028925,"score_spread":0.2564458477182077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}