{"id":"W2811499691","doi":"10.1038/s41386-018-0136-3","title":"The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Mental Health; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; National Center for PTSD, U.S. Department of Veterans Affairs; Novartis Pharma; Astellas Pharma Global Development; Genentech; Georgia Clinical and Translational Science Alliance; Astellas Pharma; Otsuka America; FORUM Pharmaceuticals; Vistagen Therapeutics; UCB Pharma; Valeant Pharmaceuticals International; H. Lundbeck A/S; Sunovion; Sanofi; National Alliance for Research on Schizophrenia and Depression; American Psychiatric Foundation; Bristol-Myers Squibb; Eli Lilly and Company; Allergan; AstraZeneca; Pfizer; Otsuka America Pharmaceutical; Amgen; National Institutes of Health; Yale Center for Clinical Investigation, Yale School of Medicine; Janssen Pharmaceuticals; Sage Therapeutics; U.S. Department of Health and Human Services; Teva Pharmaceutical Industries; U.S. Department of Veterans Affairs; Yale University","keywords":"Psychology; Neurotransmission; Glutamate receptor; Ketamine; Neuroscience; Prefrontal cortex; Medicine; Internal medicine; Cognition; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621364,0.0001878221,0.000310905,0.00008516781,0.0001523726,0.0001867562,0.00009442821,0.0002197544,0.0007494171],"category_scores_gemma":[0.0005351665,0.0001107614,0.000113401,0.00006281386,0.0001958156,0.0001348003,0.0001196509,0.0002201023,0.00008876405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094828,"about_ca_system_score_gemma":0.000130335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928831,"about_ca_topic_score_gemma":0.0037673,"domain_scores_codex":[0.9999239,0.00002887475,0.000007194859,0.00001212638,0.000009929719,0.00001803173],"domain_scores_gemma":[0.9998612,0.00003552133,0.0000306091,0.00001068629,0.00001373932,0.00004821254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3281291,0.004643971,0.3853505,0.0002453372,0.0006402718,0.001764588,0.001007642,0.0003662421,0.2111534,0.0001863764,0.0005003667,0.06601209],"study_design_scores_gemma":[0.00108179,0.01381571,0.9794875,0.000006722227,0.0001369141,0.0005266579,0.0003296707,0.0003202104,0.003944901,0.00006828728,0.0002735396,0.000008068788],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996569,0.0001566109,0.00001405228,0.00001217126,0.00000407192,0.000005046809,0.00002369479,6.064728e-7,0.0001268359],"genre_scores_gemma":[0.9995995,0.000124767,0.00004131858,0.00002258977,0.000005087914,0.00000522457,0.0000384173,5.144716e-7,0.0001624924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928831,"threshold_uncertainty_score":0.003835142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008687195299704041,"score_gpt":0.3087562674825297,"score_spread":0.3000690721828257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}