{"id":"W2812762047","doi":"10.1159/000491651","title":"N-Propargyl Caffeamide Skews Macrophages Towards a Resolving M2-Like Phenotype Against Myocardial Ischemic Injury via Activating Nrf2/HO-1 Pathway and Inhibiting NF-ĸB Pathway","year":2018,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Macrophage polarization; Chemokine; M2 Macrophage; Chemistry; In vivo; Macrophage; Pharmacology; Nitric oxide synthase; Nitric oxide; Molecular biology; Biology; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003545532,0.0004318758,0.0006888021,0.00006396725,0.0004424146,0.0000441148,0.0001063913,0.0005067688,0.0000168482],"category_scores_gemma":[0.0001490122,0.0003680616,0.0002090174,0.0001669811,0.0005742989,0.0000846589,0.000353502,0.0005740549,0.000008130382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006327989,"about_ca_system_score_gemma":0.0001642801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003164761,"about_ca_topic_score_gemma":4.657427e-7,"domain_scores_codex":[0.9978191,0.00007631091,0.000443756,0.0008716043,0.0002054011,0.0005837855],"domain_scores_gemma":[0.9988867,0.00006522628,0.0002170611,0.0004166887,0.0001712479,0.0002430787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002942917,0.00005012804,0.0003566682,0.000448323,0.0001164996,0.00002197512,0.0002884162,0.000001407672,0.9802848,0.000003805975,0.0002055929,0.01792809],"study_design_scores_gemma":[0.0008504707,0.0001865896,0.001082342,0.0003783554,0.00006889988,0.00006409426,0.0002855931,0.0007545646,0.9951341,0.00005810872,0.00072005,0.0004168919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938853,0.003273847,0.0001009231,0.00008320639,0.0002827875,0.0002341127,0.00003178739,0.0001017902,0.002006185],"genre_scores_gemma":[0.9960177,0.0002453529,0.0009120005,0.0004184308,0.001948491,0.00001569491,0.0001682779,0.0000586844,0.0002153646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0175112,"threshold_uncertainty_score":0.9998772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008045198078814333,"score_gpt":0.2264575087921659,"score_spread":0.2184123107133516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}