{"id":"W2812762047","doi":"10.1159/000491651","title":"N-Propargyl Caffeamide Skews Macrophages Towards a Resolving M2-Like Phenotype Against Myocardial Ischemic Injury via Activating Nrf2/HO-1 Pathway and Inhibiting NF-ĸB Pathway","year":2018,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Macrophage polarization; Chemokine; M2 Macrophage; Chemistry; In vivo; Macrophage; Pharmacology; Nitric oxide synthase; Nitric oxide; Molecular biology; Biology; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463922,0.0004675362,0.0002538813,0.0001756677,0.0001606719,0.0001613769,0.000169524,0.0002612658,0.001125682],"category_scores_gemma":[0.00009299249,0.00008358375,0.0003068905,0.0001022658,0.0002600265,0.000285784,0.0001098287,0.0003575534,0.0001636506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373528,"about_ca_system_score_gemma":0.0002089785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003531621,"about_ca_topic_score_gemma":0.0006276037,"domain_scores_codex":[0.9999442,0.000007621896,0.000005021414,0.00001380379,0.00001082166,0.0000184514],"domain_scores_gemma":[0.9999295,0.000005331041,0.00002737526,0.00000637485,0.00001238638,0.00001890927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002833996,0.00005452731,0.0001260724,0.000097843,0.000007319458,0.00004097585,0.000009558353,0.00002691707,0.9982067,0.00003585516,0.00002358545,0.001087137],"study_design_scores_gemma":[0.00006415093,0.001630154,0.003359725,0.00001183889,0.00004328718,0.0002194653,0.00002506472,0.0002346566,0.9924017,0.00005215394,0.00195235,0.000005423847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927412,0.003568444,0.002113576,0.0001482937,0.00004812688,0.00005241985,0.000146715,0.00003924194,0.00114189],"genre_scores_gemma":[0.9949273,0.00161133,0.001888282,0.0001303747,0.00003148408,0.00004112404,0.0001570168,0.000009842652,0.001203208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125682,"threshold_uncertainty_score":0.003765821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008045198078814333,"score_gpt":0.2264575087921659,"score_spread":0.2184123107133516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}