{"id":"W2818473048","doi":"10.1016/j.ccell.2018.05.014","title":"Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation","year":2018,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health; Sandler Foundation; National Cancer Institute; Melanoma Research Alliance","keywords":"Cancer research; CDKN2A; Melanoma; Allele; Biology; Cell biology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003779575,0.00007984884,0.00007463743,0.0000175398,0.00002557027,0.000004396366,0.00008531355,0.0000782501,0.0001101074],"category_scores_gemma":[0.000008143283,0.00007773363,0.00003415254,0.0000488283,0.00004340114,0.000002727325,0.00004407148,0.00002914687,0.000006870678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001277216,"about_ca_system_score_gemma":0.00004177882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001214966,"about_ca_topic_score_gemma":0.0001099891,"domain_scores_codex":[0.999555,0.000008945845,0.000108524,0.0001557301,0.00005706394,0.0001147299],"domain_scores_gemma":[0.9996737,0.000004733512,0.00004409569,0.0001716551,0.00007120342,0.00003457701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002392714,0.00001811103,0.002066564,0.0000345092,0.00001203654,2.827389e-7,0.00007323492,0.00007332199,0.9939622,0.000006914198,0.0006729607,0.003055977],"study_design_scores_gemma":[0.0002447785,0.0001708923,0.003206449,0.00001641175,0.000007848445,0.000001280152,0.00002893628,0.00009000087,0.9843068,0.00003624335,0.01179509,0.0000953228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850631,0.001212613,0.01080824,0.0000389651,0.0001690512,0.00007537649,0.000007216052,0.000007789314,0.002617663],"genre_scores_gemma":[0.9984316,0.0004721483,0.0003344712,0.00009462484,0.0003596318,0.00001089854,0.00003241186,0.00001404586,0.0002501273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01336855,"threshold_uncertainty_score":0.3169886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050694207453128,"score_gpt":0.2851682648689453,"score_spread":0.274661322794414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}