{"id":"W2818473048","doi":"10.1016/j.ccell.2018.05.014","title":"Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation","year":2018,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health; Sandler Foundation; National Cancer Institute; Melanoma Research Alliance","keywords":"Cancer research; CDKN2A; Melanoma; Allele; Biology; Cell biology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618645,0.0002921651,0.0001711381,0.0002544922,0.000206978,0.0004608042,0.0002464177,0.0003394466,0.001780865],"category_scores_gemma":[0.0001496258,0.000227917,0.0002207707,0.0001271363,0.00027183,0.0002165787,0.0003730733,0.000883529,0.0008569465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005480575,"about_ca_system_score_gemma":0.0002763655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531513,"about_ca_topic_score_gemma":0.004260103,"domain_scores_codex":[0.99977,0.00003075409,0.00002008978,0.00005252308,0.00007108155,0.00005557784],"domain_scores_gemma":[0.9998983,0.00001694911,0.00002485712,0.00001889383,0.000006308314,0.00003462589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006788655,0.00001672473,0.0001463008,0.00001226716,0.000003400658,0.00006692546,0.000008495661,0.0000799909,0.9985095,0.0003120652,0.00009704982,0.0006793237],"study_design_scores_gemma":[0.00001226839,0.00003261828,0.002443193,0.00000427742,0.000006359804,0.0003074582,0.00002990323,0.001958573,0.9902982,0.00009693811,0.004805119,0.000005071396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793139,0.001196176,0.008285879,0.0003457133,0.0001377245,0.00005841958,0.0009592823,0.0003590815,0.009343836],"genre_scores_gemma":[0.9927179,0.0002018461,0.001974092,0.0000596235,0.000004360449,0.00002180104,0.0002977978,0.00005212276,0.004670428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780865,"threshold_uncertainty_score":0.005957603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050694207453128,"score_gpt":0.2851682648689453,"score_spread":0.274661322794414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}