{"id":"W2819386545","doi":"10.1002/bit.26789","title":"Metabolic engineering of <i>Bacillus subtilis</i> for<scp>l</scp>‐valine overproduction","year":2018,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacillus subtilis; Overproduction; Valine; Bacillaceae; Chemistry; Biochemistry; Microbiology; Bacteria; Food science; Biology; Amino acid; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871172,0.0004682761,0.0003646233,0.0002632905,0.0001932845,0.000530982,0.0002913259,0.0002659101,0.0006494512],"category_scores_gemma":[0.0002066186,0.0001704427,0.0003239732,0.0003418048,0.0001855209,0.0001493661,0.0004536665,0.0006470531,0.0004936706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000297106,"about_ca_system_score_gemma":0.0003932246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001612548,"about_ca_topic_score_gemma":0.001875552,"domain_scores_codex":[0.9997489,0.00004890728,0.0000342282,0.000037954,0.00009080281,0.00003927645],"domain_scores_gemma":[0.9998294,0.00002141788,0.00006041291,0.00001816497,0.00002739362,0.00004307592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003019152,0.00002508647,0.00009780857,0.00003109938,0.000004032844,0.00005915645,0.00001408889,0.0001398508,0.9984124,0.00008064426,0.00004354769,0.001062013],"study_design_scores_gemma":[0.000009737267,0.0001318535,0.001128448,0.00001166509,0.00001271449,0.0002210904,0.00003644425,0.001582364,0.9933671,0.00003726007,0.003449385,0.00001197954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719427,0.0006620548,0.02102,0.0002548643,0.00007923493,0.0001334152,0.001393556,0.0004398187,0.004074338],"genre_scores_gemma":[0.9699576,0.0005388311,0.02396416,0.00006924098,0.00001130635,0.00008304742,0.002047833,0.0002194516,0.003108448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001612548,"threshold_uncertainty_score":0.003206313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005260877477562671,"score_gpt":0.1990372704766552,"score_spread":0.1937763929990926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}