{"id":"W2819386545","doi":"10.1002/bit.26789","title":"Metabolic engineering of <i>Bacillus subtilis</i> for<scp>l</scp>‐valine overproduction","year":2018,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacillus subtilis; Overproduction; Valine; Bacillaceae; Chemistry; Biochemistry; Microbiology; Bacteria; Food science; Biology; Amino acid; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178792,0.0002089197,0.0002362055,0.0001839849,0.00005795296,0.000008991687,0.0001308693,0.0003794325,0.000001328798],"category_scores_gemma":[0.0003358406,0.0002057576,0.00007127984,0.0002483968,0.0001445769,0.000008019404,0.00008042203,0.0001094639,0.000001513059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005664687,"about_ca_system_score_gemma":0.00001459461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006296508,"about_ca_topic_score_gemma":0.000002711723,"domain_scores_codex":[0.9989922,0.000006681491,0.0002393766,0.000407903,0.00005885857,0.0002949845],"domain_scores_gemma":[0.9994503,0.000008067346,0.00006940358,0.0003258791,0.0000978704,0.00004852841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001315032,0.00001932618,0.00006102931,0.0000718522,0.00008092298,1.930073e-7,0.00002106198,0.0002588205,0.994833,0.001114073,0.0002365419,0.003290056],"study_design_scores_gemma":[0.0002589936,0.0002277428,0.0003939276,0.00001634408,0.00003819001,0.00003699309,0.00002087544,0.0008157621,0.8305452,0.000009417226,0.1675452,0.00009141854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474336,0.004831684,0.04636171,0.0001317398,0.0008440381,0.0002129026,0.00003196461,0.0001296656,0.000022692],"genre_scores_gemma":[0.9886103,0.0008065068,0.009285874,0.0000196238,0.001020089,0.00001907347,0.00003820072,0.0000327864,0.0001674936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1673086,"threshold_uncertainty_score":0.8390551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005260877477562671,"score_gpt":0.1990372704766552,"score_spread":0.1937763929990926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}