{"id":"W2825062938","doi":"10.1016/j.celrep.2018.06.030","title":"Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Japan Society for the Promotion of Science; National Institute of General Medical Sciences; Medical Research Council; Mauritius Research Council; Medical Research Council Canada; National Institutes of Health; Human Frontier Science Program; Cancer Research UK; Wellcome Trust; Kindai University","keywords":"Reprogramming; Chromatin; Somatic cell; Biology; Cell biology; Transcription factor; ChIA-PET; Gene; Chromatin remodeling; Transcription (linguistics); Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131616,0.0001199309,0.000127384,0.0001391899,0.000103202,0.0003722557,0.0001173096,0.0001690924,0.002121098],"category_scores_gemma":[0.0002287068,0.00009021197,0.0001434689,0.00007262599,0.0002437222,0.0002288451,0.0002449676,0.0002851975,0.0002153492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014259,"about_ca_system_score_gemma":0.00009634079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002266854,"about_ca_topic_score_gemma":0.0003046606,"domain_scores_codex":[0.9998803,0.00002514493,0.00001116911,0.00002840915,0.00002530819,0.00002959685],"domain_scores_gemma":[0.9998176,0.00005960067,0.0000506921,0.00001884886,0.00001609794,0.00003725886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004623739,0.000006418156,0.0003557947,0.00001149466,0.000002245115,0.00004763085,0.00001307784,0.00001693005,0.9987383,0.0001310667,0.00000765709,0.0006230593],"study_design_scores_gemma":[0.0000150265,0.0002649009,0.02259728,0.000008064151,0.00001962537,0.0004578058,0.00008587098,0.0003579483,0.9736121,0.0002655828,0.002310198,0.000005673455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941784,0.001702802,0.001596207,0.00007684429,0.00003651724,0.000008966208,0.00009913436,0.00003515253,0.002265999],"genre_scores_gemma":[0.9985358,0.0003943346,0.0002377492,0.00002531007,0.00001033022,0.000003647141,0.00006743053,0.00001096463,0.0007144084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121098,"threshold_uncertainty_score":0.007095754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02803033828192737,"score_gpt":0.3130283821584808,"score_spread":0.2849980438765535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}