{"id":"W2825817435","doi":"10.1101/356386","title":"Genomic inversion drives small colony variant formation and increased virulence in <i>P. aeruginosa</i>","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Leibniz-Gemeinschaft; Medical Research Council; Deutsches Zentrum für Infektionsforschung","keywords":"Biology; Virulence; Phenotype; Transcriptome; Pseudomonas aeruginosa; Operon; Genetics; Gene; Chronic infection; Genome; Cystic fibrosis; Microbiology; Bacteria; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439389,0.0002478231,0.0001623361,0.0001770648,0.0001175569,0.0003406743,0.0002186553,0.0003402251,0.001672184],"category_scores_gemma":[0.0002351062,0.0001440803,0.0002177603,0.0001191492,0.0003052421,0.00009570077,0.0004403157,0.0007837146,0.0005884565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852268,"about_ca_system_score_gemma":0.0001476564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007877444,"about_ca_topic_score_gemma":0.0009441283,"domain_scores_codex":[0.9997624,0.00003747714,0.00001610177,0.00005621372,0.0000717061,0.00005616132],"domain_scores_gemma":[0.9997607,0.00005361722,0.00009904243,0.00003073343,0.00001465328,0.00004125495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002877412,0.00001828748,0.0001786282,0.000006931025,0.000001669278,0.00006379659,0.00001054119,0.00002847658,0.999051,0.00007460015,0.00004210963,0.0004951147],"study_design_scores_gemma":[0.00001942059,0.0002776751,0.03152847,0.00001096622,0.00001045555,0.0009664373,0.0001424173,0.002203283,0.9606608,0.000216652,0.003948449,0.00001499017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994971,0.0001907461,0.002659438,0.0001467297,0.00002688178,0.00001763791,0.0004623161,0.000134499,0.001390604],"genre_scores_gemma":[0.9965159,0.0000851093,0.0008661356,0.00006171918,0.000007308643,0.00001223532,0.0004818624,0.00006714233,0.001902636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672184,"threshold_uncertainty_score":0.005594015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008477856176627302,"score_gpt":0.1898792666357998,"score_spread":0.1814014104591725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}