{"id":"W2827741449","doi":"10.1016/j.stem.2018.05.026","title":"Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation","year":2018,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; FIS1; Stem cell; Cell biology; Myeloid leukemia; Mitochondrial fission; Function (biology); Cellular differentiation; Mitochondrion; Myeloid cells; Myeloid; Cancer research; mitochondrial fusion; Genetics; Mitochondrial DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004665293,0.0003498061,0.0003906631,0.0002009116,0.0008044445,0.0009786475,0.0003463972,0.004997682,0.008451407],"category_scores_gemma":[0.00268084,0.0001492999,0.000304733,0.0001588015,0.0009427363,0.000605303,0.0004487008,0.005096512,0.002413445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064513,"about_ca_system_score_gemma":0.0004753615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005153914,"about_ca_topic_score_gemma":0.0008530461,"domain_scores_codex":[0.9996824,0.00005590435,0.00002910243,0.00004948729,0.0001184799,0.00006463809],"domain_scores_gemma":[0.9994073,0.0003189884,0.00005119809,0.00005498965,0.00007021963,0.00009735225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002572065,0.0002986538,0.003149392,0.0002286027,0.00005995653,0.01675443,0.0001945922,0.0007424597,0.05145086,0.03700619,0.7496505,0.1378923],"study_design_scores_gemma":[0.0006800199,0.000535162,0.00239399,0.00007529458,0.00005866045,0.009176292,0.0002374681,0.001636841,0.04844854,0.03141762,0.9052954,0.00004476496],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03680123,0.01069734,0.002586625,0.8694323,0.04469556,0.00007550221,0.0006067615,0.0005300162,0.03457468],"genre_scores_gemma":[0.537394,0.01481004,0.003850829,0.2952341,0.04953108,0.0002521451,0.0005906637,0.0001948432,0.09814224],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008451407,"threshold_uncertainty_score":0.02827275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128314606783548,"score_gpt":0.2359802718466786,"score_spread":0.2246971257788432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}