{"id":"W2830736422","doi":"10.2337/db18-0417","title":"High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph","keywords":"ATP–ADP translocase; Mitochondrion; Mitochondrial biogenesis; Bioenergetics; ANT; Biology; Skeletal muscle; Internal medicine; Endocrinology; Adenosine diphosphate; Adenosine triphosphate; Insulin resistance; Inner mitochondrial membrane; Biochemistry; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738688,0.0003674666,0.0002510826,0.0003700472,0.0001582443,0.000269808,0.0001545317,0.0003159799,0.001305373],"category_scores_gemma":[0.0001108137,0.0002083876,0.000236633,0.00029899,0.000333841,0.0002220966,0.0002882479,0.0006461078,0.0001762989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002345031,"about_ca_system_score_gemma":0.0001543445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003338471,"about_ca_topic_score_gemma":0.0007446649,"domain_scores_codex":[0.9998543,0.00002981768,0.00001957848,0.00003533233,0.00003213127,0.00002878092],"domain_scores_gemma":[0.9998448,0.00001910309,0.00005702966,0.00002429831,0.00001386933,0.00004097785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007681302,0.00007165194,0.001871838,0.00006086934,0.0000300773,0.0001977827,0.00001664537,0.00006582605,0.9948307,0.0001870098,0.00006592539,0.001833501],"study_design_scores_gemma":[0.00007202428,0.0012655,0.04683123,0.00002840769,0.00009211904,0.001428002,0.00009002108,0.001363991,0.9451916,0.0005478417,0.003075355,0.00001381537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935836,0.001093505,0.003874623,0.0001527275,0.00003664732,0.00001663513,0.0002694388,0.00006404793,0.0009088321],"genre_scores_gemma":[0.995924,0.0008399598,0.001616796,0.00009805601,0.00001173766,0.0000242239,0.0002924566,0.00001325647,0.001179407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305373,"threshold_uncertainty_score":0.004366875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418265724982922,"score_gpt":0.2594349691759564,"score_spread":0.2452523119261271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}