{"id":"W2830736422","doi":"10.2337/db18-0417","title":"High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph","keywords":"ATP–ADP translocase; Mitochondrion; Mitochondrial biogenesis; Bioenergetics; ANT; Biology; Skeletal muscle; Internal medicine; Endocrinology; Adenosine diphosphate; Adenosine triphosphate; Insulin resistance; Inner mitochondrial membrane; Biochemistry; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478361,0.0001492517,0.0004134824,0.00009232577,0.00006517088,0.000008691495,0.00003654177,0.0001199415,0.0002340382],"category_scores_gemma":[0.0006117287,0.0001234282,0.00009799012,0.0001778182,0.0001919642,0.00009850501,0.00003710031,0.0001041048,0.0002921127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001992822,"about_ca_system_score_gemma":0.0000542666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401151,"about_ca_topic_score_gemma":0.00004132784,"domain_scores_codex":[0.998922,0.00007899111,0.000238414,0.0002457727,0.0002355599,0.0002791905],"domain_scores_gemma":[0.9990523,0.0001210547,0.0001107512,0.0003406815,0.0002464931,0.000128718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008099572,0.0001753839,0.007862702,0.00006944718,0.0001945433,0.00002137419,0.0005304243,5.43595e-7,0.967868,0.0003813738,0.0174428,0.004643448],"study_design_scores_gemma":[0.002279144,0.001641963,0.07367721,0.0001310983,0.0003860134,0.00000559654,0.00007213496,0.00004133343,0.904762,0.0004197659,0.01642315,0.00016058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965628,0.0003042905,0.00002262433,0.0003895566,0.001385016,0.000277868,0.0000364432,0.00008869549,0.0009327286],"genre_scores_gemma":[0.9942572,0.00001796587,0.0006319512,0.0003570346,0.002699025,0.00001119267,0.00005845724,0.00002361304,0.001943602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06581451,"threshold_uncertainty_score":0.5033256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418265724982922,"score_gpt":0.2594349691759564,"score_spread":0.2452523119261271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}