{"id":"W2831862991","doi":"10.1016/j.ahj.2018.07.002","title":"A comparison of the effects of selective and non-selective mineralocorticoid antagonism on glucose homeostasis of heart failure patients with glucose intolerance or type II diabetes: A randomized controlled double-blind trial","year":2018,"lang":"en","type":"letter","venue":"American Heart Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Montreal Heart Institute","funders":"Bristol-Myers Squibb Canada; Novartis; ARCA Biopharma; Roche; Bayer; AstraZeneca; AstraZeneca Canada; Servier; Pfizer; Fonds de Recherche du Québec - Santé; Pfizer Canada; Abbott Laboratories","keywords":"Spironolactone; Medicine; Eplerenone; Mineralocorticoid receptor; Glucose homeostasis; Heart failure; Internal medicine; Mineralocorticoid; Type 2 diabetes; Randomized controlled trial; Endocrinology; Impaired glucose tolerance; Diabetes mellitus; Homeostasis; Aldosterone; Blood sugar regulation; Cardiology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005081882,0.0004350471,0.005047312,0.0004005189,0.0001755485,0.00001952852,0.0001203978,0.0002441798,0.00001958295],"category_scores_gemma":[0.001042106,0.0002160079,0.0005675727,0.0006999332,0.001115729,0.000065198,0.0000453369,0.001278019,9.684884e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020705,"about_ca_system_score_gemma":0.0006872224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009030181,"about_ca_topic_score_gemma":0.00001222607,"domain_scores_codex":[0.9962898,0.0007131872,0.001223911,0.000341636,0.001066939,0.0003644949],"domain_scores_gemma":[0.9941587,0.001642544,0.001992342,0.0003137183,0.001742665,0.0001500363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9412896,0.0007762139,0.005140894,0.0001721989,0.001671318,0.000007919142,0.000725983,0.000003619082,0.007495905,4.728936e-7,0.04198253,0.0007333357],"study_design_scores_gemma":[0.9143612,0.03167814,0.0132176,0.001686545,0.002008735,0.00004902803,0.00006726034,0.0001500372,0.03384582,0.000006236813,0.002660631,0.0002687664],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768,0.0005886926,0.000009380825,0.01718964,0.0002918485,0.005083972,0.00001299023,0.000007355393,0.00001612906],"genre_scores_gemma":[0.9844803,0.00009800462,0.0005441264,0.0139873,0.0006888073,0.00008049051,0.00002017477,0.00005240544,0.00004837562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0393219,"threshold_uncertainty_score":0.8808548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580710863271736,"score_gpt":0.2974625141498574,"score_spread":0.2816554055171401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}