{"id":"W2834973095","doi":"10.1002/cpt.1179","title":"Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes","year":2018,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; BC Children’s Hospital Foundation; BC Children's Hospital; Children's Hospital Foundation; London Health Sciences Centre","keywords":"Pharmacogenomics; Peripheral neuropathy; Pharmacokinetics; Medicine; Pharmacogenetics; Pharmacology; Vincristine; Gene; Bioinformatics; Internal medicine; Genetics; Biology; Chemotherapy; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107646,0.0003528717,0.0005428647,0.0005335977,0.0001584069,0.0006593739,0.0001871591,0.0002995632,0.001589353],"category_scores_gemma":[0.002298155,0.000127356,0.0009703319,0.001554437,0.0001948986,0.000195212,0.0002852192,0.0004265463,0.00011267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038174,"about_ca_system_score_gemma":0.0002708004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002404993,"about_ca_topic_score_gemma":0.003695254,"domain_scores_codex":[0.9991689,0.0003492747,0.00006318883,0.0002389746,0.0001409785,0.00003862122],"domain_scores_gemma":[0.9984671,0.0008486293,0.0004136678,0.0001429955,0.00008815054,0.00003944111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003796511,0.0001041732,0.8363957,0.001732803,0.02623723,0.0007237644,0.000162463,0.004396657,0.01938686,0.001440558,0.002314686,0.1033086],"study_design_scores_gemma":[0.000194608,0.0004499865,0.9628664,0.0002058219,0.01780595,0.001371354,0.00008343887,0.003869904,0.004211912,0.002391777,0.00652286,0.00002588501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9380394,0.05081132,0.003834799,0.001101838,0.0000478342,0.00002504172,0.003963511,0.00004587632,0.002130368],"genre_scores_gemma":[0.9917066,0.005640115,0.0009159692,0.0002545243,0.00003886046,0.00001370941,0.0009887835,0.00001489107,0.0004265097],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002404993,"threshold_uncertainty_score":0.005692959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2432248406893961,"score_gpt":0.5059146346413825,"score_spread":0.2626897939519864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}