{"id":"W2841326852","doi":"10.1002/anie.201806412","title":"Surprising Antibacterial Activity and Selectivity of Hydrophilic Polyphosphoniums Featuring Sugar and Hydroxy Substituents","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada","keywords":"Selectivity; Sugar; Chemistry; Antibacterial activity; Stereochemistry; Combinatorial chemistry; Organic chemistry; Bacteria; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006865938,0.0001255043,0.0001370133,0.00004241727,0.0001281149,0.0000485762,0.00009506965,0.00009463811,0.0003166897],"category_scores_gemma":[0.00003943425,0.0001301559,0.00003161076,0.00007804685,0.0002035835,0.0002560428,0.00008775278,0.0001070501,0.000003296213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005287646,"about_ca_system_score_gemma":0.00002104333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004599472,"about_ca_topic_score_gemma":0.00005662415,"domain_scores_codex":[0.999283,0.000005296929,0.0001478316,0.0002724529,0.0001577725,0.0001336341],"domain_scores_gemma":[0.9995157,0.00003575239,0.0001430605,0.0001107024,0.0001390388,0.00005577566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006922477,0.00007956191,0.003883116,0.00003030182,0.00004220664,0.00000127308,0.0001037539,2.677382e-7,0.9943091,0.00008547586,0.0003220424,0.001073632],"study_design_scores_gemma":[0.0003999414,0.00001364384,0.01902649,0.00006732206,0.00002045623,0.00002511405,0.00001191637,0.00007963848,0.9784064,0.0001449314,0.001680471,0.0001236433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948031,0.00002519251,0.0004966805,0.0001630585,0.0002728057,0.00004857365,0.0001143087,0.00003474626,0.004041557],"genre_scores_gemma":[0.9983813,0.00009658076,0.0001260435,0.00002542161,0.001036174,0.000005737646,0.0001097171,0.00001353773,0.0002054923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01590271,"threshold_uncertainty_score":0.5307603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00939349839919747,"score_gpt":0.2416798319042074,"score_spread":0.2322863335050099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}