{"id":"W2845852940","doi":"10.3748/wjg.v24.i25.2686","title":"Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond","year":2018,"lang":"en","type":"review","venue":"World Journal of Gastroenterology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Texas MD Anderson Cancer Center; Astellas Pharma; Broad Institute; National Cancer Institute; University of Rochester; Case Western Reserve University; University of Pittsburgh; Nationwide Children's Hospital; Memorial Sloan-Kettering Cancer Center; Vanderbilt University; University of Washington; BC Cancer Agency; Eli Lilly and Company; KU Leuven; Brown University; Van Andel Research Institute; University of Southern California","keywords":"Pembrolizumab; Microsatellite instability; Cancer; Medicine; Blockade; Oncology; Immunotherapy; PD-L1; Biomarker; Internal medicine; Cancer research; Receptor; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009943018,0.0007234466,0.001254329,0.002712028,0.0002145677,0.001110408,0.0005904194,0.001113215,0.002109969],"category_scores_gemma":[0.001317634,0.0002371846,0.0006886402,0.001889458,0.0004868112,0.001530659,0.0006035187,0.002227024,0.001007704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005719387,"about_ca_system_score_gemma":0.001155706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007790163,"about_ca_topic_score_gemma":0.001215628,"domain_scores_codex":[0.9997112,0.00006188432,0.00004721012,0.00004262258,0.0001141444,0.00002290915],"domain_scores_gemma":[0.9991649,0.0004337418,0.0001070174,0.00002156765,0.0002306606,0.00004214597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007334689,0.00006966459,0.0005350462,0.0155687,0.0001195724,0.0002159625,0.00007535692,0.0002819821,0.002007629,0.003764892,0.02797077,0.9493171],"study_design_scores_gemma":[0.00001963226,0.0001460885,0.001751178,0.005223308,0.0001979425,0.002259935,0.00009000978,0.000187346,0.001016693,0.002903347,0.9861754,0.00002904907],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001114005,0.9986525,0.0001316275,0.0004391025,0.0002119883,0.000003570324,0.00001248661,0.000005490561,0.0004318414],"genre_scores_gemma":[0.0009941931,0.9976739,0.0002749833,0.0003554202,0.000286382,0.000006964975,0.00002888937,0.000001526757,0.0003777437],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002712028,"threshold_uncertainty_score":0.007058561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879248585291886,"score_gpt":0.3592188708300455,"score_spread":0.3304263849771266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}