{"id":"W2846124355","doi":"10.1038/s41380-018-0298-8","title":"Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups","year":2018,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Servier; Eisai; IXICO; University of Pittsburgh; Pfizer; Biogen; BioClinica; Northern California Institute for Research and Education; Nancy and Buster Alvord Endowment; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; University of Southern California; H. Lundbeck A/S; U.S. Department of Veterans Affairs; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Psychology; Disease; Dementia; Psychiatry; Medicine; Neuroscience; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006377866,0.0003781143,0.0007095768,0.002715378,0.0006136696,0.001423602,0.0005485885,0.0006413534,0.00164161],"category_scores_gemma":[0.01387963,0.0001681234,0.001558087,0.002704086,0.0005488895,0.0005977605,0.0008882399,0.0005174488,0.0001201874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739585,"about_ca_system_score_gemma":0.0003345595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002625364,"about_ca_topic_score_gemma":0.002821404,"domain_scores_codex":[0.9946849,0.002525351,0.001054199,0.0009411003,0.0005739468,0.000220489],"domain_scores_gemma":[0.9829437,0.007745919,0.005830338,0.002000489,0.001006755,0.0004727098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001127053,0.00003029536,0.9883292,0.0001372049,0.003205264,0.0001466003,0.0003005041,0.0003223136,0.001726107,0.0002391146,0.0002249382,0.004211389],"study_design_scores_gemma":[0.00006187174,0.0001926328,0.9943141,0.00006504577,0.001245177,0.0003849121,0.0004768084,0.000573374,0.0006537311,0.001199499,0.000815571,0.00001721774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939329,0.002393387,0.001213389,0.0002035193,0.00002244171,0.00001676791,0.001451727,0.000009832092,0.0007560829],"genre_scores_gemma":[0.9991609,0.00006948085,0.000202107,0.00005049544,0.0000103957,0.000006736084,0.0004601764,0.000002607833,0.00003719602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006377866,"threshold_uncertainty_score":0.03372973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609305319226438,"score_gpt":0.3214144488560235,"score_spread":0.2953213956637591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}