{"id":"W2846124355","doi":"10.1038/s41380-018-0298-8","title":"Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups","year":2018,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Servier; Eisai; IXICO; University of Pittsburgh; Pfizer; Biogen; BioClinica; Northern California Institute for Research and Education; Nancy and Buster Alvord Endowment; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; University of Southern California; H. Lundbeck A/S; U.S. Department of Veterans Affairs; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Psychology; Disease; Dementia; Psychiatry; Medicine; Neuroscience; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035265,0.0001969051,0.0001909956,0.0001247688,0.0001343801,0.00005703224,0.0002149121,0.00005023201,0.0003992027],"category_scores_gemma":[0.00007396976,0.0001807294,0.00005784004,0.0002140649,0.0003011509,0.00007883392,0.0003069357,0.000157881,0.0002635494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008364934,"about_ca_system_score_gemma":0.0002735251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001876359,"about_ca_topic_score_gemma":0.00001360499,"domain_scores_codex":[0.9982719,0.00009965001,0.0002086304,0.0006035747,0.0004118972,0.0004043297],"domain_scores_gemma":[0.9986026,0.00002227342,0.00004670633,0.0006983285,0.0001634282,0.0004667215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007017885,0.0004369708,0.9774233,0.00007436305,0.0003584412,0.0003463272,0.00003164497,3.284423e-8,0.0009487962,0.0001129013,0.007249722,0.01231573],"study_design_scores_gemma":[0.002383954,0.0006012876,0.9890149,0.0001050679,0.0008748259,0.0000917237,0.00005903623,0.000508331,0.0005853137,0.001408936,0.00413661,0.0002300053],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849722,0.004544501,0.002602867,0.003652436,0.0002276068,0.0006075196,0.0001564024,0.00006273066,0.003173726],"genre_scores_gemma":[0.9917293,0.00008736952,0.003942586,0.003416092,0.0002477457,0.00002839125,0.0003170191,0.00004098066,0.0001905106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01208573,"threshold_uncertainty_score":0.736993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609305319226438,"score_gpt":0.3214144488560235,"score_spread":0.2953213956637591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}