{"id":"W2848978533","doi":"10.1016/j.jacc.2018.04.054","title":"The Evolving Future of PCSK9 Inhibitors","year":2018,"lang":"en","type":"review","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":264,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"PCSK9; Medicine; Ezetimibe; Proprotein convertase; Kexin; Clinical trial; Coronary artery disease; Internal medicine; Monoclonal antibody; Disease; Acute coronary syndrome; Cholesterol; LDL receptor; Pharmacology; Lipoprotein; Antibody; Immunology; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001202247,0.0007619656,0.00206108,0.001734857,0.0002689642,0.001845034,0.001074562,0.001721112,0.004637763],"category_scores_gemma":[0.002306451,0.0003166533,0.0009642829,0.001379716,0.0005988388,0.002135649,0.0008265817,0.003251346,0.001230027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005967359,"about_ca_system_score_gemma":0.001354777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008535851,"about_ca_topic_score_gemma":0.002216476,"domain_scores_codex":[0.9995986,0.00007129487,0.00008269813,0.00007035052,0.000135097,0.00004192752],"domain_scores_gemma":[0.9987459,0.0007797862,0.0001673644,0.00002312662,0.0002038135,0.00007987169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000234523,0.00008387902,0.000267136,0.01563707,0.0002079317,0.0002203058,0.00004586212,0.000349803,0.000620015,0.004141726,0.04506713,0.9331246],"study_design_scores_gemma":[0.0001534515,0.0002220704,0.001094864,0.005998189,0.0004877844,0.00106473,0.00007343008,0.0002670421,0.0002744535,0.003367322,0.986959,0.00003760835],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007112867,0.9985558,0.00006421045,0.0006796353,0.0003027597,0.000001616077,0.0000143971,0.000005645324,0.0003047333],"genre_scores_gemma":[0.0007669652,0.9969067,0.000162332,0.001010731,0.0007921966,0.000004191752,0.00003307546,0.000001867042,0.000321902],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004637763,"threshold_uncertainty_score":0.01551491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722825365685192,"score_gpt":0.30324153793483,"score_spread":0.2860132842779781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}