{"id":"W2850515277","doi":"10.1111/cea.13220","title":"Population pharmacokinetics of subcutaneous C1‐inhibitor for prevention of attacks in patients with hereditary angioedema","year":2018,"lang":"en","type":"article","venue":"Clinical & Experimental Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"BioCryst; CSL Behring","keywords":"Pharmacokinetics; Medicine; NONMEM; Hereditary angioedema; Bioavailability; Pharmacology; Population; Dosing; Volume of distribution; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001623721,0.0002522659,0.00056613,0.0002069512,0.00008385383,0.0004450205,0.0001826409,0.0004144074,0.0005908582],"category_scores_gemma":[0.002765462,0.0001407315,0.0002961931,0.0001469896,0.0001276541,0.0002225184,0.0001447591,0.0004048161,0.0001170587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282934,"about_ca_system_score_gemma":0.0003767582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008665638,"about_ca_topic_score_gemma":0.0005234428,"domain_scores_codex":[0.9995161,0.0002718319,0.0000196369,0.00009397179,0.00007356359,0.00002493243],"domain_scores_gemma":[0.9987934,0.0007782315,0.0002340919,0.00006824539,0.00006986932,0.00005615517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03039719,0.001688484,0.4814757,0.0007021872,0.003163064,0.001356356,0.0009770088,0.122025,0.1389398,0.001224573,0.003983925,0.2140667],"study_design_scores_gemma":[0.00190495,0.02404368,0.6181036,0.00008084549,0.001603768,0.002573019,0.0002091604,0.3066832,0.03761067,0.001645605,0.005412858,0.0001286813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892681,0.001821971,0.007569859,0.00009937367,0.000007492356,0.00009191578,0.0003465501,0.0001054135,0.000689166],"genre_scores_gemma":[0.9981287,0.0001409515,0.001314089,0.00003122696,0.000007701183,0.00004204966,0.0002256001,0.000006724577,0.0001029215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623721,"threshold_uncertainty_score":0.008587182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042902967857374,"score_gpt":0.3681053508937389,"score_spread":0.3376763212151652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}