{"id":"W2850515277","doi":"10.1111/cea.13220","title":"Population pharmacokinetics of subcutaneous C1‐inhibitor for prevention of attacks in patients with hereditary angioedema","year":2018,"lang":"en","type":"article","venue":"Clinical & Experimental Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"BioCryst; CSL Behring","keywords":"Pharmacokinetics; Medicine; NONMEM; Hereditary angioedema; Bioavailability; Pharmacology; Population; Dosing; Volume of distribution; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670646,0.0001717495,0.0005168256,0.00008339412,0.00003514285,0.000003911511,0.00008173665,0.0001398584,0.000198773],"category_scores_gemma":[0.00006552717,0.0001489965,0.0002195351,0.000143107,0.0002100734,0.00008792746,0.00004286971,0.0000701533,0.000003536106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004723856,"about_ca_system_score_gemma":0.00003933905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006635616,"about_ca_topic_score_gemma":0.0000377753,"domain_scores_codex":[0.9980929,0.00005629067,0.001026389,0.0003195785,0.000295136,0.0002096782],"domain_scores_gemma":[0.9989738,0.0001353597,0.0003571177,0.0002185896,0.0002006685,0.000114505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01750397,0.008789835,0.9406483,0.0001810967,0.0004522501,0.00001562129,0.0008154202,0.00003413836,0.007012131,0.0003065373,0.002505596,0.02173516],"study_design_scores_gemma":[0.01475929,0.01734538,0.8941787,0.0004642701,0.0001085569,0.00001008165,0.0002366642,0.0009155668,0.07032203,0.0001761615,0.001189866,0.0002934005],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979115,0.0004430528,0.00009059886,0.00005818143,0.0005153764,0.0007588251,0.00002165141,0.00002319557,0.0001776538],"genre_scores_gemma":[0.9969487,0.00001631449,0.001834727,0.00009439954,0.0005412149,0.00002373249,0.0002969777,0.00003358498,0.0002103265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0633099,"threshold_uncertainty_score":0.6075901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042902967857374,"score_gpt":0.3681053508937389,"score_spread":0.3376763212151652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}