{"id":"W2850757991","doi":"10.24953/turkjped.2017.06.001","title":"Dermal fibroblast transcriptome indicates contribution of WNT signaling pathways in the pathogenesis of Apert syndrome","year":2017,"lang":"en","type":"article","venue":"The Turkish Journal of Pediatrics","topic":"Craniofacial Disorders and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Hacettepe Üniversitesi","keywords":"Apert syndrome; Wnt signaling pathway; Craniosynostosis; Medicine; Fibroblast; Genetics; Dysostosis; Biology; Transcriptome; Gene; Cell biology; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005229366,0.0001041017,0.0002173724,0.00005524674,0.0001276636,0.00002407023,0.0004828751,0.00009163812,0.000004660476],"category_scores_gemma":[0.0001631551,0.00006127304,0.0001813114,0.00007509063,0.0001028423,0.00001062449,0.00003771457,0.0001061813,4.593271e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008332502,"about_ca_system_score_gemma":0.0000744651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002642954,"about_ca_topic_score_gemma":0.000009940924,"domain_scores_codex":[0.9990604,0.00008829269,0.0003915916,0.00008505965,0.0002303968,0.0001442397],"domain_scores_gemma":[0.9989493,0.00004270576,0.0006276608,0.0002043187,0.0001444083,0.00003155093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003203198,0.0004338767,0.09523748,0.00006978676,0.000111002,0.00007058128,0.0008575079,0.0001864964,0.9010716,0.0001067706,0.00009863309,0.00143597],"study_design_scores_gemma":[0.004278945,0.001761628,0.8725116,0.0000942294,0.0005413426,0.0003997338,0.001074765,0.00001934336,0.1176634,0.001138402,0.0002265044,0.0002900715],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997369,0.001954177,0.0002044452,0.0001818774,0.00008100253,0.0001204943,0.00005737863,7.788076e-7,0.00003086236],"genre_scores_gemma":[0.9987671,0.001028063,0.00004114792,0.00002944949,0.0001077052,0.000002158294,0.00001311889,0.00000791339,0.000003288315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7834082,"threshold_uncertainty_score":0.2498642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186634309907047,"score_gpt":0.2401308743598138,"score_spread":0.2282645312607433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}