{"id":"W2852385583","doi":"10.1371/journal.pcbi.1006303","title":"Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics","year":2018,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Paxillin; Focal adhesion; Cell biology; Phosphorylation; Cell adhesion; Cytoskeleton; Serine; GTPase; PAK1; Chemistry; Adhesion; Biology; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005728631,0.0001076746,0.00009694431,0.0000404637,0.000132182,0.00001036176,0.00004073175,0.0001162031,0.0000274102],"category_scores_gemma":[0.00006573414,0.000100397,0.00002359706,0.00003668585,0.00004090598,0.000003661859,0.0001013291,0.00005428986,0.0000298164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002176052,"about_ca_system_score_gemma":0.00001368201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002809315,"about_ca_topic_score_gemma":0.00001763111,"domain_scores_codex":[0.9993844,0.00004716912,0.0001183933,0.0002860707,0.00005049082,0.0001134496],"domain_scores_gemma":[0.9996438,0.00006120882,0.00005867187,0.00007733795,0.0001065033,0.00005249642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002079706,0.00007348193,0.001580312,0.00002615376,0.00007123004,0.00000163834,0.00002743892,0.00007166436,0.9811543,0.009689415,0.0001994956,0.00689696],"study_design_scores_gemma":[0.001052476,0.002863045,0.009750142,0.00003721996,0.00003205749,0.00005636802,0.00001120482,0.1922089,0.7795251,0.004425431,0.009711002,0.0003270002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965383,0.0003979795,0.002255314,0.0002551366,0.0001772011,0.000146806,0.00002999631,0.00001103866,0.0001882659],"genre_scores_gemma":[0.9977618,0.0001554976,0.0005265254,0.0003650848,0.000184695,0.00001116668,0.0008052775,0.00001179544,0.0001781702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2016291,"threshold_uncertainty_score":0.4094069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087203237911733,"score_gpt":0.240539991916904,"score_spread":0.2324527886789923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}