{"id":"W285283909","doi":"10.1139/y08-050","title":"Sustained Ca<sup>2+</sup>signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ fingerThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.","year":2008,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"PDZ domain; Internalization; Förster resonance energy transfer; Receptor; HEK 293 cells; G protein-coupled receptor; Chemistry; Cell biology; Biophysics; Immunoprecipitation; Signal transduction; Yellow fluorescent protein; Biochemistry; Biology; Fluorescence; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003792826,0.0001156974,0.0003310193,0.0001494885,0.00005259533,0.000003572555,0.0001134434,0.0001635283,0.001521772],"category_scores_gemma":[0.0001051226,0.00009133132,0.00005131589,0.0001422915,0.0001964384,0.00001818286,0.00001174913,0.0002054792,1.524801e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003288174,"about_ca_system_score_gemma":0.0002511799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008291707,"about_ca_topic_score_gemma":0.001270504,"domain_scores_codex":[0.9987722,0.0003323365,0.0004551101,0.0001578288,0.00007678715,0.0002057151],"domain_scores_gemma":[0.9992337,0.00008661103,0.0003772046,0.00005627493,0.0001766987,0.00006949008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00116956,0.00008330919,0.002846238,0.00002666113,0.0001921401,0.000007431258,0.004734831,0.00194515,0.9881468,0.00001545798,0.0006661577,0.00016624],"study_design_scores_gemma":[0.002730683,0.001993961,0.0006485689,0.00007006118,0.00005437692,0.00002667329,0.0008422633,0.0006968219,0.9918891,0.00019132,0.0007509921,0.0001051358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991601,0.0001846708,0.00005746762,0.0002431501,0.0001094985,0.0001550974,0.00003672406,6.396226e-7,0.00005266305],"genre_scores_gemma":[0.9987596,0.0002533681,0.0001176728,0.0005212504,0.0002895533,0.000004581464,0.00001743231,0.000009535391,0.00002695263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003892567,"threshold_uncertainty_score":0.999391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117988146969911,"score_gpt":0.2310599673711551,"score_spread":0.219880085901456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}