{"id":"W285283909","doi":"10.1139/y08-050","title":"Sustained Ca<sup>2+</sup>signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ fingerThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.","year":2008,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"PDZ domain; Internalization; Förster resonance energy transfer; Receptor; HEK 293 cells; G protein-coupled receptor; Chemistry; Cell biology; Biophysics; Immunoprecipitation; Signal transduction; Yellow fluorescent protein; Biochemistry; Biology; Fluorescence; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391674,0.0002680636,0.0002400478,0.0001341257,0.0001729315,0.0004411177,0.000208682,0.0003882526,0.001712108],"category_scores_gemma":[0.00008617058,0.0001581535,0.0002627048,0.0001703829,0.0002289555,0.0003177444,0.0002205284,0.0006740582,0.0006617467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002951141,"about_ca_system_score_gemma":0.00009259977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728845,"about_ca_topic_score_gemma":0.0002364399,"domain_scores_codex":[0.9998442,0.00001417944,0.00001579481,0.00004895329,0.00004112597,0.00003569653],"domain_scores_gemma":[0.9999135,0.000009842077,0.00003273595,0.00001099735,0.000009667652,0.00002321951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340957,0.00001871155,0.0001786575,0.00001185855,0.000003528476,0.00009747216,0.000007559189,0.00001176088,0.9991164,0.00005978195,0.00004344284,0.0003166771],"study_design_scores_gemma":[0.00003537718,0.0001518174,0.02402201,0.000005152661,0.000012945,0.001343745,0.00006149852,0.001159986,0.9712759,0.00009905269,0.001824692,0.000007733666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943468,0.0009418954,0.003060391,0.0001419752,0.00005147692,0.0000220477,0.000358931,0.00006154063,0.001015001],"genre_scores_gemma":[0.9932503,0.0003750002,0.001662156,0.0000977729,0.00001720634,0.00004397653,0.0007129521,0.00002589071,0.003814933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712108,"threshold_uncertainty_score":0.005727589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117988146969911,"score_gpt":0.2310599673711551,"score_spread":0.219880085901456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}