{"id":"W2855531598","doi":"10.1182/bloodadvances.2017011643","title":"The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance","year":2018,"lang":"en","type":"article","venue":"Blood Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Umm Al-Qura University","keywords":"Von Willebrand factor; In vivo; Von Willebrand disease; Population; Linkage disequilibrium; Internal medicine; Endocrinology; Biology; Messenger RNA; Recombinant DNA; Genotype; Single-nucleotide polymorphism; Chemistry; Molecular biology; Genetics; Platelet; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004144571,0.001123061,0.0006477899,0.0006761398,0.0004671904,0.0006411246,0.0005450895,0.001533879,0.01209011],"category_scores_gemma":[0.001594431,0.0001770001,0.0008606715,0.0008274446,0.0006903698,0.0003719383,0.0003571543,0.0008728868,0.002071603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004459575,"about_ca_system_score_gemma":0.0004300638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347338,"about_ca_topic_score_gemma":0.001420788,"domain_scores_codex":[0.9993268,0.0001368042,0.000101669,0.0001817936,0.0001755466,0.00007734889],"domain_scores_gemma":[0.9991879,0.0001926458,0.0003465814,0.00006672333,0.00007573084,0.0001303352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007861329,0.0006407452,0.24018,0.0008646889,0.001987466,0.08127081,0.0006435831,0.003193297,0.4878168,0.01186947,0.01569381,0.1479782],"study_design_scores_gemma":[0.0008161297,0.002178863,0.4555142,0.0007516044,0.001571292,0.2845061,0.0004195498,0.0056253,0.1561757,0.01484145,0.07728337,0.0003164643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601858,0.008930679,0.006204824,0.002604224,0.0009443842,0.000147565,0.004740104,0.0003057044,0.01593668],"genre_scores_gemma":[0.9912789,0.0009314547,0.002267334,0.0005204317,0.0002583161,0.00002810997,0.0009479315,0.0000806339,0.003686815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209011,"threshold_uncertainty_score":0.04044545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127184067684439,"score_gpt":0.24896415034546,"score_spread":0.2376923096686156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}