{"id":"W2863793278","doi":"10.1007/s10549-018-4876-x","title":"CYP2D6 genotype and endoxifen plasma concentration do not predict hot flash severity during tamoxifen therapy","year":2018,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Tamoxifen; Hot flash; Genotype; Breast cancer; Oncology; Medicine; CYP2D6; Internal medicine; Flash (photography); Biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017345,0.0002271401,0.0005197517,0.0002549979,0.0001504632,0.0004099778,0.0001626309,0.0004370508,0.001591428],"category_scores_gemma":[0.001765072,0.0001339304,0.0005286648,0.0003510837,0.0001541927,0.0002449501,0.0001249104,0.0003709082,0.0002275772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001452972,"about_ca_system_score_gemma":0.0001099283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000932807,"about_ca_topic_score_gemma":0.001930357,"domain_scores_codex":[0.9997606,0.00007375328,0.00002916447,0.00004604609,0.00004937199,0.00004111084],"domain_scores_gemma":[0.998623,0.0005174558,0.0005721201,0.00007268067,0.00006070033,0.0001539812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002090717,0.00006557487,0.9896707,0.00002490228,0.0002898425,0.000188763,0.00003548778,0.00008037665,0.002597779,0.0000194588,0.000146778,0.004789711],"study_design_scores_gemma":[0.00001323741,0.0001433681,0.9989464,0.000003266284,0.00006551873,0.0002793788,0.00002519078,0.0001652489,0.0001999351,0.00002191919,0.0001341222,0.000002505539],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981153,0.0007407356,0.0001027006,0.00008444324,0.00001647915,0.000004788257,0.0001864742,0.00000485194,0.000744345],"genre_scores_gemma":[0.9994432,0.0001056742,0.00003504623,0.00003280845,0.00001543933,0.00000190045,0.0001414574,0.000002218124,0.0002221497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591428,"threshold_uncertainty_score":0.005323827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958720750246877,"score_gpt":0.3069828849859282,"score_spread":0.2873956774834594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}