{"id":"W2872999080","doi":"10.1016/j.celrep.2018.06.041","title":"Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention; Grand Challenges Canada; Chinese Center for Disease Control and Prevention; Tsinghua University; National Natural Science Foundation of China; Salt Science Research Foundation","keywords":"Epitope; Middle East respiratory syndrome coronavirus; Neutralization; Glycoprotein; Mutagenesis; Binding site; Viral entry; Plasma protein binding; Antibody; Cell biology; Chemistry; Receptor; Biology; Virology; Computational biology; Mutation; Molecular biology; Virus; Genetics; Coronavirus disease 2019 (COVID-19); Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009420993,0.0002199945,0.0001584625,0.00009772928,0.0001207418,0.0001602905,0.0001856235,0.0002441111,0.0004241283],"category_scores_gemma":[0.0001191853,0.00009334618,0.0002415732,0.00005756957,0.0002197081,0.0001950773,0.0002075357,0.0004649123,0.0001316284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002125965,"about_ca_system_score_gemma":0.0002582643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003141467,"about_ca_topic_score_gemma":0.0004345893,"domain_scores_codex":[0.9999616,0.00000757718,0.00000322955,0.000007527599,0.00001134479,0.000008746102],"domain_scores_gemma":[0.9999456,0.000008683878,0.00001604409,0.000008248551,0.000007262222,0.00001403269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008150904,0.00002952202,0.0007190829,0.00002348519,0.000004666967,0.0002450497,0.00002256527,0.0003244778,0.9962897,0.0004947806,0.0000296473,0.001735541],"study_design_scores_gemma":[0.00004832206,0.0008460006,0.01581471,0.00001339523,0.00003810681,0.002654926,0.0001088583,0.006137571,0.9688524,0.0006758865,0.004794854,0.00001503188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993317,0.0004024702,0.005111706,0.00007869609,0.00001836754,0.00002445818,0.00007020815,0.0000251382,0.0009519445],"genre_scores_gemma":[0.9929608,0.000244418,0.006018081,0.00008202201,0.000009674251,0.000009038521,0.0002209807,0.000003924835,0.0004511124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004241283,"threshold_uncertainty_score":0.001542509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04546689603264886,"score_gpt":0.3140209531938486,"score_spread":0.2685540571611997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}