{"id":"W2873519758","doi":"10.1021/acs.oprd.8b00145","title":"Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone","year":2018,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Innovative Microfluidic and Catalytic Techniques Innovation","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex Pharmachem (Canada)","funders":"","keywords":"Deoxygenation; Yield (engineering); Sodium borohydride; Continuous stirred-tank reactor; Chemistry; Borane; Indole test; Continuous flow; Process (computing); Flow chemistry; Process engineering; Chemical engineering; Combinatorial chemistry; Organic chemistry; Catalysis; Materials science; Computer science; Metallurgy; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002948321,0.0001293939,0.0002309915,0.0003913517,0.00009394651,0.00001259453,0.0004389807,0.00009254384,0.00004368501],"category_scores_gemma":[0.0007121617,0.0001040771,0.00001704908,0.00195275,0.0002523332,0.0001386416,0.00003971659,0.0001979972,0.000005273214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028833,"about_ca_system_score_gemma":0.000389576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003524761,"about_ca_topic_score_gemma":0.000003277309,"domain_scores_codex":[0.9983271,0.00004889946,0.0005291176,0.0002026246,0.0005670368,0.0003252725],"domain_scores_gemma":[0.9974766,0.0001494566,0.00009062014,0.0001930471,0.002071921,0.00001834472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117152,0.0002129607,0.0001599644,0.001322146,0.00009586073,0.000001216332,0.01872889,0.000009342183,0.8847549,0.001492249,0.001148974,0.09195636],"study_design_scores_gemma":[0.0002047367,0.00008052722,0.001163536,0.0001835644,0.000004231795,0.000003130316,0.002370788,0.000285389,0.9931364,0.001898502,0.0005551417,0.0001140352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8318743,0.0002124713,0.1632762,0.0002280402,0.00007656793,0.001511013,0.00002048918,0.00008500223,0.002715973],"genre_scores_gemma":[0.9968616,0.00002335215,0.002452764,0.00001064148,0.00004847259,0.0005191108,0.00002114445,0.00002978615,0.00003317677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1649873,"threshold_uncertainty_score":0.4244142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352849760537027,"score_gpt":0.3315043174577436,"score_spread":0.2979758198523733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}