{"id":"W2873769715","doi":"10.3389/fnins.2018.00476","title":"Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; IXICO; H. Lundbeck A/S; Eisai; Janssen Alzheimer Immunotherapy Research And Development; Rainwater Charitable Foundation; Servier; American Society of Neuroradiology; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Genentech; Larry L. Hillblom Foundation; F. Hoffmann-La Roche; Johnson and Johnson Pharmaceutical Research and Development; Radiological Society of North America; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Genetically modified mouse; Transgene; Insulin-like growth factor; Disease; Pathology; Growth factor; Biology; Medicine; Neuroscience; Internal medicine; Gene; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002585366,0.0006757636,0.0004783823,0.002123039,0.000315966,0.0005613468,0.0003275662,0.000659317,0.002866353],"category_scores_gemma":[0.0002321997,0.0005669913,0.0005488181,0.0009143052,0.0003899227,0.0002646488,0.0003413639,0.001136494,0.001013052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004728289,"about_ca_system_score_gemma":0.0001981334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009763686,"about_ca_topic_score_gemma":0.001621601,"domain_scores_codex":[0.999481,0.00004425536,0.00005787161,0.0001803721,0.0001574014,0.00007904818],"domain_scores_gemma":[0.9996248,0.00003688323,0.0001783323,0.00002828485,0.00002971708,0.0001019493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003816052,0.00008422106,0.00122443,0.00003523562,0.00002805175,0.0002436194,0.00003151703,0.00002104778,0.9960228,0.00007045272,0.000175854,0.001681109],"study_design_scores_gemma":[0.0002433371,0.001731125,0.2157092,0.00006910587,0.0002731228,0.01075611,0.0001933538,0.002222239,0.7516404,0.0006921526,0.01640236,0.00006747099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776458,0.003107951,0.01087619,0.0003982518,0.0001191095,0.00009370095,0.004470444,0.0006874421,0.002601179],"genre_scores_gemma":[0.9666231,0.002855762,0.01249693,0.0003398218,0.00005590171,0.0003070808,0.007459055,0.0003322681,0.009530069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002866353,"threshold_uncertainty_score":0.009588897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746587268706388,"score_gpt":0.2446768328620795,"score_spread":0.2272109601750157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}