{"id":"W2874147448","doi":"10.1177/2472555218787468","title":"First Nonphosphorylated Inhibitors of Phosphoglucose Isomerase Identified by Chemical Library Screening","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; Centro Nacional de Pesquisa em Energia e Materiais; Fundação de Amparo à Pesquisa do Estado de São Paulo; York University; Laboratório Nacional de Biociências; University of South Carolina","keywords":"Trypanosoma brucei; Trypanosoma cruzi; Glucose-6-phosphate isomerase; Leishmania mexicana; Antiparasitic agent; Leishmania; Biochemistry; Biology; Kinetoplastida; African trypanosomiasis; Antiparasitic; Leishmaniasis; Drug discovery; Isomerase; Enzyme; Pharmacology; Virology; Parasite hosting; Trypanosomiasis; Medicine; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753547,0.001060335,0.001005397,0.001269718,0.0003290677,0.0006105473,0.0008210925,0.0004686215,0.005047993],"category_scores_gemma":[0.0003419265,0.0002867305,0.000588955,0.001171786,0.0002600438,0.0003918845,0.0005891953,0.0007687027,0.001369492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005691845,"about_ca_system_score_gemma":0.0006230491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007757047,"about_ca_topic_score_gemma":0.003499404,"domain_scores_codex":[0.9997498,0.00003526272,0.00001582612,0.00004823076,0.00009688907,0.00005387199],"domain_scores_gemma":[0.999859,0.00002673765,0.00002465648,0.00001372201,0.00003886203,0.00003700907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012578,0.001430118,0.001199508,0.002268296,0.0002662109,0.001212121,0.0001672572,0.004586102,0.8712016,0.002224068,0.005102986,0.1093291],"study_design_scores_gemma":[0.001285743,0.01214091,0.006728257,0.0002354628,0.0007409556,0.002387486,0.0001600546,0.007086305,0.8963433,0.001008478,0.07176201,0.0001210826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8268111,0.06944746,0.03769765,0.001282531,0.0003785241,0.003142674,0.01215613,0.001903518,0.04718051],"genre_scores_gemma":[0.8761895,0.05040076,0.02706384,0.001292381,0.0001117211,0.001078104,0.01734312,0.0001944321,0.02632595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005047993,"threshold_uncertainty_score":0.01688725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090116528081037,"score_gpt":0.2606513406569844,"score_spread":0.2497501753761741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}