{"id":"W2874147448","doi":"10.1177/2472555218787468","title":"First Nonphosphorylated Inhibitors of Phosphoglucose Isomerase Identified by Chemical Library Screening","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; Centro Nacional de Pesquisa em Energia e Materiais; Fundação de Amparo à Pesquisa do Estado de São Paulo; York University; Laboratório Nacional de Biociências; University of South Carolina","keywords":"Trypanosoma brucei; Trypanosoma cruzi; Glucose-6-phosphate isomerase; Leishmania mexicana; Antiparasitic agent; Leishmania; Biochemistry; Biology; Kinetoplastida; African trypanosomiasis; Antiparasitic; Leishmaniasis; Drug discovery; Isomerase; Enzyme; Pharmacology; Virology; Parasite hosting; Trypanosomiasis; Medicine; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002512368,0.0001760595,0.0002938457,0.0001177082,0.00009628426,0.00008810609,0.0002092823,0.0001225702,0.0006621984],"category_scores_gemma":[0.0002159403,0.0001568992,0.0001588492,0.0005916566,0.0004737234,0.0007529776,0.0002021235,0.0002321951,0.0001662136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004058421,"about_ca_system_score_gemma":0.0001781099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001358927,"about_ca_topic_score_gemma":0.000007000358,"domain_scores_codex":[0.9984243,0.0000197472,0.0003956202,0.0003561085,0.0004145617,0.00038967],"domain_scores_gemma":[0.9988536,0.00008929132,0.0001083177,0.0005217135,0.0000935451,0.0003334901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001149848,0.0006674109,0.01860194,0.0001072643,0.000187544,0.0000240057,0.0002647454,7.390465e-7,0.6393979,0.0007111242,0.3367484,0.00213903],"study_design_scores_gemma":[0.001646882,0.0003297065,0.0261667,0.0002057677,0.00003929455,0.00001847854,0.0002076178,0.0001232222,0.9419634,0.0001558681,0.02896697,0.0001760379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905477,0.001178017,0.0009073122,0.001564412,0.0001778941,0.0003800757,0.0002192358,0.0001046792,0.004920724],"genre_scores_gemma":[0.9916352,0.0001834021,0.0008112161,0.0003162611,0.0002967054,0.00002957652,0.0002766765,0.00004616116,0.006404778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3077814,"threshold_uncertainty_score":0.7250608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090116528081037,"score_gpt":0.2606513406569844,"score_spread":0.2497501753761741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}