{"id":"W2874588853","doi":"10.1093/cvr/cvy181","title":"Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein","year":2018,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fundamental Research Funds for the Central Universities; China Postdoctoral Science Foundation; Natural Science Foundation of Shaanxi Province; National Natural Science Foundation of China","keywords":"Transcytosis; Cell biology; Matrix (chemical analysis); Chemistry; Biology; Endocytosis; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166826,0.0003123537,0.0003118273,0.0001669169,0.0001616497,0.0005912176,0.0001868943,0.0002792695,0.0008414937],"category_scores_gemma":[0.0001717202,0.0001412444,0.000245567,0.0001244726,0.0003158952,0.000264823,0.0002398924,0.0006775467,0.0002653209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291107,"about_ca_system_score_gemma":0.000212401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004756038,"about_ca_topic_score_gemma":0.0006363083,"domain_scores_codex":[0.9998091,0.00003675346,0.00001472956,0.00005105418,0.00003681636,0.00005147409],"domain_scores_gemma":[0.9998398,0.00002541959,0.00005998348,0.00001987926,0.00002314816,0.00003186701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001863126,0.00003109136,0.0001270804,0.00003513038,0.000004425774,0.00001935124,0.00001519857,0.00003356105,0.9985273,0.00008759562,0.00003315247,0.0008998446],"study_design_scores_gemma":[0.00004081408,0.0003463397,0.004589113,0.000007343063,0.0000267795,0.0001105537,0.00004828716,0.001805231,0.9913309,0.00005248414,0.001636388,0.000005771172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916366,0.002519409,0.004676446,0.0001187322,0.00005409567,0.0000242615,0.0001294028,0.0001365345,0.0007045317],"genre_scores_gemma":[0.9954424,0.0008598964,0.002465687,0.00004713729,0.00001038697,0.00002997652,0.0001124673,0.00002486157,0.00100711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008414937,"threshold_uncertainty_score":0.002815068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09145457719237748,"score_gpt":0.4049314026996556,"score_spread":0.3134768255072781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}