{"id":"W2882552267","doi":"10.1186/s12864-018-4892-6","title":"Novel long-range regulatory mechanisms controlling PKD2 gene expression","year":2018,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Fondation Maladies Rares","keywords":"Biology; CTCF; Chromatin; Enhancer; Promoter; Chromosome conformation capture; Regulation of gene expression; Gene; ChIA-PET; Genetics; Gene expression; Regulatory sequence; Reporter gene; Chromatin remodeling; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450382,0.000233749,0.0001230152,0.0001646545,0.0001848528,0.0005240288,0.0002813353,0.0003438147,0.001279477],"category_scores_gemma":[0.0002140095,0.0001438253,0.0001669858,0.0001204739,0.0003729751,0.0002989566,0.0003228351,0.0004283313,0.0003233332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004723429,"about_ca_system_score_gemma":0.0001880357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000350906,"about_ca_topic_score_gemma":0.0006925975,"domain_scores_codex":[0.999832,0.00001265811,0.000007321664,0.00008084863,0.00004012034,0.00002701492],"domain_scores_gemma":[0.9998401,0.00005061466,0.00003932224,0.00001894675,0.00002053064,0.00003039984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005958395,0.000008425805,0.001061702,0.00003519106,0.000002883979,0.00008756962,0.00002757598,0.0001171413,0.9966263,0.000373594,0.0000284195,0.001571556],"study_design_scores_gemma":[0.00003831973,0.0001621554,0.03932336,0.00002366549,0.00001799476,0.001200311,0.00009214738,0.003808412,0.9491231,0.0006276311,0.00556642,0.00001647439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569317,0.004244415,0.03523105,0.0001971363,0.00004186892,0.00003807293,0.0004632309,0.0001807273,0.00267184],"genre_scores_gemma":[0.9907418,0.0003973544,0.006951731,0.0000433181,0.00001761561,0.00002821783,0.0004603301,0.00001549797,0.00134421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279477,"threshold_uncertainty_score":0.004280269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375504818045951,"score_gpt":0.2278527414160436,"score_spread":0.2140976932355841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}