{"id":"W2883011405","doi":"10.1530/rep-18-0218","title":"Transposons and the PIWI pathway: genome defense in gametes and embryos","year":2018,"lang":"en","type":"review","venue":"Reproduction","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; CReATe Fertility Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Michelson Prize and Grants","keywords":"Piwi-interacting RNA; Biology; Reprogramming; Genetics; Argonaute; Epigenetics; Transposable element; Genome; Chromatin; DNA methylation; RNA; Cell biology; RNA interference; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438014,0.0005244799,0.0006669493,0.001532728,0.0002601713,0.0006917255,0.0004775208,0.0007945528,0.002608022],"category_scores_gemma":[0.0002971573,0.0001616178,0.0002458135,0.001042494,0.0003557682,0.000845436,0.0004733047,0.001053191,0.00141168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004099049,"about_ca_system_score_gemma":0.0007081905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007695082,"about_ca_topic_score_gemma":0.001247767,"domain_scores_codex":[0.9999228,0.000009626946,0.00001230404,0.00001768802,0.00002806274,0.000009623001],"domain_scores_gemma":[0.9998951,0.00004087757,0.00001652088,0.000003022717,0.0000294808,0.00001499804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005589949,0.0000487207,0.000295182,0.01088734,0.00004763514,0.0003702041,0.00009947994,0.0002914018,0.004679822,0.006080455,0.01455706,0.9625869],"study_design_scores_gemma":[0.000006129009,0.00007206886,0.001006764,0.001537584,0.00004962866,0.001786519,0.00007424342,0.00006784262,0.001002521,0.002185341,0.9921973,0.00001392018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002106522,0.9979462,0.0001709708,0.0001840703,0.000128597,0.000003343305,0.00001668788,0.00000805133,0.001331387],"genre_scores_gemma":[0.001244538,0.9974278,0.0001684114,0.0001113382,0.0001169519,0.000004248167,0.00002804376,0.000001498727,0.0008971657],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002608022,"threshold_uncertainty_score":0.008724749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03819057660114807,"score_gpt":0.2434387774234623,"score_spread":0.2052482008223143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}