{"id":"W2883011405","doi":"10.1530/rep-18-0218","title":"Transposons and the PIWI pathway: genome defense in gametes and embryos","year":2018,"lang":"en","type":"review","venue":"Reproduction","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; CReATe Fertility Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Michelson Prize and Grants","keywords":"Piwi-interacting RNA; Biology; Reprogramming; Genetics; Argonaute; Epigenetics; Transposable element; Genome; Chromatin; DNA methylation; RNA; Cell biology; RNA interference; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004592972,0.0001531225,0.0004045416,0.00001518317,0.0001547626,0.00004664886,0.0000787641,0.0001152375,0.0000417861],"category_scores_gemma":[0.00009050006,0.00004498528,0.00009742122,0.000281031,0.0001555441,0.0000371037,0.00003463705,0.0001247722,0.00001223774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001381658,"about_ca_system_score_gemma":0.00001165764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104842,"about_ca_topic_score_gemma":0.0003265873,"domain_scores_codex":[0.9988391,0.0001908916,0.000247276,0.000514883,0.00007682122,0.0001310482],"domain_scores_gemma":[0.9995899,0.0001430326,0.0001026054,0.0001050818,0.00002510309,0.00003431449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007023738,0.00002151217,0.00001845132,0.0002787584,0.00001762332,8.25464e-7,0.0001425862,1.460026e-7,0.0001611176,0.0002456138,0.00001088153,0.9990954],"study_design_scores_gemma":[0.0001003936,0.00006607175,0.002184359,0.0003245669,0.0001105522,0.0001006166,0.0000357877,0.000002255912,0.000005041956,0.0009663894,0.9959616,0.0001423561],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02254269,0.9758517,3.596679e-7,0.0007373394,0.0001228841,0.000567843,0.0000401873,0.00002135666,0.0001156004],"genre_scores_gemma":[0.002557521,0.9962624,0.00002895832,0.00001290583,0.0007396323,0.00006444835,0.00005912205,0.000001296831,0.0002737605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9989531,"threshold_uncertainty_score":0.1834446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03819057660114807,"score_gpt":0.2434387774234623,"score_spread":0.2052482008223143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}