{"id":"W2883021501","doi":"10.1002/acn3.615","title":"Pre‐amyloid stage of Alzheimer's disease in cognitively normal individuals","year":2018,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; ZonMw; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Stage (stratigraphy); Disease; Alzheimer's disease; Amyloid (mycology); Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003941482,0.000411704,0.000358196,0.0006358969,0.000522084,0.0007135172,0.0002810104,0.0005285461,0.002017729],"category_scores_gemma":[0.001963067,0.00028142,0.0003709242,0.0004683691,0.0002599249,0.0004426436,0.0002776929,0.000679387,0.0004627897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284335,"about_ca_system_score_gemma":0.0003244652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008415492,"about_ca_topic_score_gemma":0.008236188,"domain_scores_codex":[0.9998618,0.00002918395,0.00001301235,0.00003770501,0.00002719766,0.00003108186],"domain_scores_gemma":[0.9992571,0.0001246657,0.0002598498,0.00004593468,0.0001075063,0.0002049314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007291291,0.0001283562,0.9966067,0.00001116256,0.00005190978,0.0002387228,0.00008962853,0.00005552878,0.0005175832,0.00002306749,0.0001158153,0.001432405],"study_design_scores_gemma":[0.000007984435,0.0001699646,0.9994029,0.000001503706,0.00001425912,0.0001881359,0.00003605472,0.00007027519,0.00002733815,0.00002449254,0.00005560816,0.000001507157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992638,0.0001584933,0.00003479884,0.00002409167,0.000006967869,0.000004916714,0.0001253693,0.000003542217,0.0003780082],"genre_scores_gemma":[0.9992981,0.00005143498,0.00005010903,0.00002274142,0.00001220359,0.000006791105,0.0001701206,0.000001398522,0.0003871029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008415492,"threshold_uncertainty_score":0.01673299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1519163441932452,"score_gpt":0.4447004370887457,"score_spread":0.2927840928955005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}