{"id":"W2883021501","doi":"10.1002/acn3.615","title":"Pre‐amyloid stage of Alzheimer's disease in cognitively normal individuals","year":2018,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; ZonMw; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Stage (stratigraphy); Disease; Alzheimer's disease; Amyloid (mycology); Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004242375,0.0001117025,0.0004462523,0.0001252373,0.0000282113,0.0000025226,0.00005582543,0.0001020883,0.0002762838],"category_scores_gemma":[0.0001646936,0.00009258629,0.0001562349,0.0001217203,0.0009642895,0.00008728675,0.00002595874,0.0001859677,0.000009948136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":1.017388e-7,"about_ca_system_score_gemma":0.000233669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003757726,"about_ca_topic_score_gemma":0.00001165197,"domain_scores_codex":[0.9982751,0.0002114238,0.0007118873,0.0002714169,0.0003054904,0.000224696],"domain_scores_gemma":[0.9985551,0.0005833498,0.0001409991,0.0001187188,0.0002492438,0.0003525894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006346776,0.001175756,0.9853391,0.00004052031,0.001345765,0.00006663927,0.0000373349,0.000002777736,0.00000428559,0.0006065271,0.00004076096,0.004993765],"study_design_scores_gemma":[0.003219507,0.00174308,0.991519,0.00002660376,0.00020904,0.000003231027,0.000001907645,0.0001871201,0.0003012338,0.002289279,0.0004400437,0.0000600025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906934,0.002192299,0.000009805419,0.005466885,0.00003479491,0.0003258405,0.0004748503,0.000007187899,0.0007949449],"genre_scores_gemma":[0.998122,0.0004058137,0.00007138881,0.001171908,0.0001175202,0.00001090597,0.00007787456,0.000009319814,0.00001326625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00742861,"threshold_uncertainty_score":0.3775559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1519163441932452,"score_gpt":0.4447004370887457,"score_spread":0.2927840928955005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}