{"id":"W2883049349","doi":"10.1016/j.jogc.2018.01.007","title":"Enhanced First Trimester Aneuploidy Screening with Placental Growth Factor and Alpha Feto-Protein: Detection of Trisomies 18 and 13","year":2018,"lang":"en","type":"article","venue":"Journal of Obstetrics and Gynaecology Canada","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"North York General Hospital; University of Toronto","funders":"North York General Hospital; Australian Federal Police","keywords":"Trisomy; Aneuploidy; Down syndrome; Medicine; Pregnancy-associated plasma protein A; Obstetrics; Second trimester; Placental growth factor; Pregnancy; First trimester; Andrology; Gynecology; Fetus; Internal medicine; Biology; Genetics; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061846,0.0001294151,0.0003696679,0.0001837224,0.0001186329,0.00001668647,0.00004464395,0.000103649,0.00002829185],"category_scores_gemma":[0.002198425,0.0000957919,0.00002359255,0.0001844767,0.0001828325,0.0000993134,0.00003777196,0.0002240084,6.742859e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001192549,"about_ca_system_score_gemma":0.000301389,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008068045,"about_ca_topic_score_gemma":0.01711401,"domain_scores_codex":[0.9991282,0.00002935994,0.0003112929,0.0001342232,0.0002181426,0.0001787554],"domain_scores_gemma":[0.9979609,0.001150844,0.0003198998,0.00006626468,0.0002779517,0.0002241642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00108258,0.0001895729,0.8306144,0.0004493204,0.0005733412,0.001438224,0.0006953178,0.000007909699,0.006891896,0.00002234455,0.0005209984,0.1575141],"study_design_scores_gemma":[0.006396687,0.004714802,0.95469,0.0000732344,0.0001521231,0.0003318267,0.0003862747,0.0001254303,0.0324909,0.00001476605,0.000482105,0.0001417795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959135,0.002447318,0.0005752056,0.0001527503,0.0005509934,0.0001433211,0.00001676624,0.000003864247,0.0001962697],"genre_scores_gemma":[0.9988976,0.0001529929,0.0007346984,0.0001014933,0.00004569485,0.000001352498,0.000001373899,0.00001074072,0.00005412605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1573723,"threshold_uncertainty_score":0.9985373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152548603495098,"score_gpt":0.2181754132372429,"score_spread":0.2066499272022919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}