{"id":"W2883073823","doi":"10.3389/fphar.2018.00828","title":"SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"GIS-Institut des Maladies Rares; Sorbonne Université; Association Vaincre la Mucoviscidose; Institut National de la Santé et de la Recherche Médicale; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Cystic fibrosis; Medicine; Internal medicine; Pharmacogenomics; Pulmonary function testing; Lung; Cohort; Oncology; Cystic fibrosis transmembrane conductance regulator; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004758276,0.0002225137,0.0004684751,0.0007075664,0.00007114767,0.00001317367,0.0001512336,0.0001220064,0.0003814342],"category_scores_gemma":[0.0004550136,0.0001815711,0.00002924023,0.001137488,0.0002444154,0.0001476953,0.00006965908,0.0003303298,0.00003009911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009752854,"about_ca_system_score_gemma":0.000238086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003281903,"about_ca_topic_score_gemma":0.00002514737,"domain_scores_codex":[0.9977025,0.0003417778,0.0003087666,0.0005083665,0.0004678406,0.0006707318],"domain_scores_gemma":[0.9989243,0.0002169486,0.00009633868,0.0002179281,0.0002856197,0.0002589337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1423064,0.0005205525,0.7295033,0.00003964722,0.0002334975,0.0001099472,0.0003397722,0.00007035641,0.02026329,3.855196e-7,0.1051976,0.001415274],"study_design_scores_gemma":[0.01533625,0.008348485,0.9595492,0.0002026267,0.0001579475,0.000005610133,0.00008914099,0.001818505,0.006718684,0.00001825373,0.007496464,0.0002588595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993903,0.000164444,0.003313419,0.0005749629,0.0005666114,0.001275687,0.00005467878,0.00004639096,0.0001008351],"genre_scores_gemma":[0.9854614,0.000006939309,0.01205131,0.001365096,0.0001282067,0.0001801069,0.00005172788,0.0000459817,0.0007092469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2300459,"threshold_uncertainty_score":0.7404253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006637752868097146,"score_gpt":0.2868823077665489,"score_spread":0.2802445548984518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}