{"id":"W2883073823","doi":"10.3389/fphar.2018.00828","title":"SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"GIS-Institut des Maladies Rares; Sorbonne Université; Association Vaincre la Mucoviscidose; Institut National de la Santé et de la Recherche Médicale; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Cystic fibrosis; Medicine; Internal medicine; Pharmacogenomics; Pulmonary function testing; Lung; Cohort; Oncology; Cystic fibrosis transmembrane conductance regulator; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273699,0.0003241412,0.0003677299,0.0004241032,0.0003909684,0.0003111805,0.0001835016,0.0005026339,0.002089505],"category_scores_gemma":[0.0009240624,0.0001371588,0.0005325038,0.0005430293,0.0001969394,0.0001465967,0.0001858207,0.0004313103,0.0001861343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194943,"about_ca_system_score_gemma":0.0001398442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003371504,"about_ca_topic_score_gemma":0.002961564,"domain_scores_codex":[0.9997212,0.00005684647,0.00003603718,0.00009984004,0.00004474872,0.00004133914],"domain_scores_gemma":[0.9993733,0.0001527368,0.0002848858,0.00004168908,0.00004446633,0.0001030126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005775503,0.00003726556,0.9944671,0.00001405346,0.0001117228,0.0004313946,0.00005422035,0.00005966514,0.00269276,0.00002179412,0.0001093111,0.001423165],"study_design_scores_gemma":[0.00001161557,0.00009709462,0.9989018,0.000003905506,0.00003507625,0.0005852044,0.00003147407,0.0001189606,0.00009064942,0.00001402653,0.0001078144,0.000002500654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993661,0.0002607055,0.00004385816,0.00003441426,0.000004167182,0.000002875648,0.0001230663,0.000002255357,0.0001626324],"genre_scores_gemma":[0.9996728,0.00004454585,0.00003465378,0.00001771259,0.000007382981,0.000003020748,0.0001163286,0.000001345451,0.0001022156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003371504,"threshold_uncertainty_score":0.006990075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006637752868097146,"score_gpt":0.2868823077665489,"score_spread":0.2802445548984518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}