{"id":"W2883138099","doi":"10.1097/01.tp.0000542905.98105.1f","title":"Humanization and Pre-Clinical Validation of an Anti-HLA-A*02","year":2018,"lang":"en","type":"article","venue":"Transplantation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Immunogenicity; Polyclonal antibodies; Human leukocyte antigen; Antigen; Immunology; Humanized mouse; Chimeric antigen receptor; Antibody; Biology; Immunotherapy; Computational biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003384737,0.0004918198,0.0001815273,0.0002765162,0.0002501689,0.0008853084,0.0006195729,0.0006996068,0.004403245],"category_scores_gemma":[0.001278385,0.0001477453,0.0003286491,0.0001784902,0.0005765411,0.0003550265,0.0003950824,0.0007733038,0.001311821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004301005,"about_ca_system_score_gemma":0.001031887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004627959,"about_ca_topic_score_gemma":0.0003564352,"domain_scores_codex":[0.9986572,0.0005593345,0.0001158771,0.0001891537,0.000296341,0.0001820855],"domain_scores_gemma":[0.9991998,0.000145038,0.00009093322,0.0001575403,0.000264327,0.0001424561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003044801,0.003815199,0.01758116,0.0005575959,0.0001169448,0.0006695347,0.0003421922,0.001334379,0.8052052,0.003151273,0.006005277,0.1581764],"study_design_scores_gemma":[0.001202948,0.05055618,0.02504031,0.0002591678,0.0001721763,0.005220842,0.0003211415,0.002665514,0.7361445,0.001077667,0.1773013,0.00003820265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9224853,0.005780681,0.04158947,0.001975276,0.0004785984,0.004153975,0.002202294,0.0003656365,0.02096877],"genre_scores_gemma":[0.9683239,0.002044706,0.01575836,0.001671621,0.0001443785,0.001314915,0.003259192,0.00005596088,0.007427002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004403245,"threshold_uncertainty_score":0.01790041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06023133680711768,"score_gpt":0.4084449172840989,"score_spread":0.3482135804769812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}