{"id":"W2883139774","doi":"10.1016/j.nicl.2018.07.016","title":"Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment","year":2018,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Hemispheric Asymmetry in Neuroscience","field":"Neuroscience","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Eisai; Servier; U.S. Department of Defense; Eli Lilly and Company; Lundbeckfonden; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Merck; Alzheimer's Drug Discovery Foundation; IXICO; Takeda Pharmaceutical Company; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Lateralization of brain function; Dementia; Positron emission tomography; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Psychology; Atrophy; Alzheimer's disease; Pittsburgh compound B; Internal medicine; Cardiology; Cognitive impairment; Cognitive decline; Medicine; Fluorodeoxyglucose; Audiology; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007975925,0.0005154461,0.0007416005,0.0001608794,0.0003181187,0.0001918143,0.000833932,0.000187061,0.0002765346],"category_scores_gemma":[0.00502344,0.0004200671,0.0002361404,0.001060946,0.002634587,0.0006228399,0.0004056371,0.001007176,0.0003263489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004772684,"about_ca_system_score_gemma":0.0002384175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006337104,"about_ca_topic_score_gemma":0.00007723161,"domain_scores_codex":[0.9937356,0.00133331,0.00103265,0.002032508,0.0008028869,0.001063122],"domain_scores_gemma":[0.9955713,0.002744333,0.0003355581,0.0006815141,0.0001792431,0.0004880736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0124344,0.009586629,0.5402962,0.00009692745,0.00008096058,0.01016603,0.005308303,0.00004005159,0.4069402,0.0006045213,0.00510605,0.009339692],"study_design_scores_gemma":[0.007946375,0.002842213,0.711495,0.0001591939,0.00009021427,0.0004007406,0.0001901142,0.00423504,0.2695187,0.0001222134,0.002099371,0.0009008662],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930874,0.00001913647,0.0003175403,0.00137812,0.001077745,0.0008659568,0.0001161849,0.0002072147,0.002930761],"genre_scores_gemma":[0.9832429,0.00005649512,0.001147811,0.01425654,0.0004728135,0.00003111762,0.000003829996,0.00007814483,0.0007103629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1711988,"threshold_uncertainty_score":0.9998251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.056587485159138,"score_gpt":0.3636440856818237,"score_spread":0.3070566005226857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}