{"id":"W2883157667","doi":"10.1093/nar/gky662","title":"miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5′ UTR RNA to stabilize and promote viral RNA accumulation","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Icahn School of Medicine at Mount Sinai","keywords":"Biology; Untranslated region; RNA; Five prime untranslated region; Internal ribosome entry site; Viral replication; Virology; NS2-3 protease; Three prime untranslated region; Hepatitis C virus; Genetics; RNA-dependent RNA polymerase; RNA interference; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001309817,0.0002146686,0.0003138138,0.0003022465,0.0007509032,0.0001572458,0.0004703937,0.0002008596,0.0003187306],"category_scores_gemma":[0.002452566,0.000136012,0.00005865446,0.00110174,0.001598506,0.000221799,0.0005970701,0.0009723342,0.0000192907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095812,"about_ca_system_score_gemma":0.0003920555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004178195,"about_ca_topic_score_gemma":0.003069629,"domain_scores_codex":[0.9960604,0.0007146142,0.00046135,0.0005520438,0.001494124,0.0007175042],"domain_scores_gemma":[0.9969845,0.0004382311,0.00009287642,0.0008513607,0.001281934,0.0003510517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003182749,0.00008816527,0.03074021,0.0001905386,0.00008200462,0.00001710207,0.006739495,0.00001118663,0.9302329,0.0002648702,0.0005937766,0.03072147],"study_design_scores_gemma":[0.003470788,0.002363164,0.4201556,0.0006348489,0.00008370355,0.00005743168,0.0005842008,0.04161925,0.5236745,0.003425461,0.003556981,0.0003741052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925703,0.0001121766,0.0001726014,0.003507343,0.00008475006,0.002247406,0.0003408648,0.00004250629,0.0009220749],"genre_scores_gemma":[0.9972744,0.0001665917,0.001647198,0.0002291881,0.0002689821,0.00005459862,0.0000272038,0.00005466276,0.000277168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4065584,"threshold_uncertainty_score":0.6316209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008976884261117,"score_gpt":0.398269102542065,"score_spread":0.2973714141159534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}