{"id":"W2883157667","doi":"10.1093/nar/gky662","title":"miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5′ UTR RNA to stabilize and promote viral RNA accumulation","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Icahn School of Medicine at Mount Sinai","keywords":"Biology; Untranslated region; RNA; Five prime untranslated region; Internal ribosome entry site; Viral replication; Virology; NS2-3 protease; Three prime untranslated region; Hepatitis C virus; Genetics; RNA-dependent RNA polymerase; RNA interference; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195511,0.0004353921,0.0002415907,0.0001836479,0.0002608807,0.0002992139,0.0001709075,0.0003229888,0.001251365],"category_scores_gemma":[0.0002638909,0.0002371328,0.0003788107,0.0001208317,0.0002359803,0.000150185,0.000171181,0.0003734128,0.0005341409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290513,"about_ca_system_score_gemma":0.0002280526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000292233,"about_ca_topic_score_gemma":0.0005070988,"domain_scores_codex":[0.9998115,0.00003941196,0.00002170247,0.00005159094,0.00005296798,0.00002289533],"domain_scores_gemma":[0.999892,0.00002073782,0.00003720195,0.00002090836,0.00001098658,0.00001823114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000627955,0.00001782329,0.0001567119,0.00002895641,0.000004689252,0.00003796891,0.000006465363,0.0001141152,0.9979361,0.0001943866,0.00003396358,0.001406023],"study_design_scores_gemma":[0.00001033087,0.0002418347,0.001312755,0.000002914606,0.00001439548,0.00029045,0.000004113473,0.001381062,0.9940699,0.0000671392,0.002599226,0.00000590583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740813,0.002089159,0.01877651,0.0001078524,0.0001308771,0.0001146047,0.0003695769,0.0004445661,0.003885468],"genre_scores_gemma":[0.9836791,0.0005982738,0.01202079,0.00006803303,0.00001924574,0.00005298883,0.0004746195,0.00005988592,0.00302699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251365,"threshold_uncertainty_score":0.004186273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008976884261117,"score_gpt":0.398269102542065,"score_spread":0.2973714141159534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}