{"id":"W2883221795","doi":"10.1002/ana.25294","title":"Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease","year":2018,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Medical Research Council Canada; University of Bristol; British Heart Foundation; University College London; University College London Hospitals NHS Foundation Trust; Parkinson's UK; EU Joint Programme – Neurodegenerative Disease Research; National Institute for Health and Care Research; Barts Charity; Wellcome Trust; Medical Research Council; National Institute on Handicapped Research","keywords":"Mendelian randomization; Confounding; Internal medicine; Confidence interval; Odds ratio; Hyperuricemia; Medicine; Observational study; Context (archaeology); Oncology; Uric acid; Genetics; Biology; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005633776,0.000161457,0.0004176019,0.0001670012,0.0001219048,0.00001057042,0.00007914154,0.0001090044,0.00006174341],"category_scores_gemma":[0.00189303,0.0001477566,0.00005495321,0.0002087907,0.0001717868,0.000112711,0.00007078584,0.0002220801,0.00003046396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004506689,"about_ca_system_score_gemma":0.0000658752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003220498,"about_ca_topic_score_gemma":0.000007854864,"domain_scores_codex":[0.9983196,0.0003643378,0.0004337502,0.0003820837,0.0002302231,0.0002700317],"domain_scores_gemma":[0.9984184,0.0005341579,0.0002156131,0.0003422366,0.0002734078,0.0002161914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001050663,0.00010976,0.9966353,0.0000325835,0.00008960866,0.00007049987,0.0003848233,0.00001393973,0.0006661752,0.00004624501,0.0004355596,0.0004648752],"study_design_scores_gemma":[0.003921897,0.001341195,0.9919419,0.00001232056,0.0002629794,0.00002473404,0.00002963763,0.0007520727,0.0001349315,0.000340003,0.001129602,0.0001086866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941562,0.00008807947,0.0002736555,0.004074719,0.0001297423,0.0006423468,0.00002344779,0.00004796843,0.0005638815],"genre_scores_gemma":[0.9974599,0.000006559046,0.00009122436,0.00182725,0.0004456601,0.00001836546,0.00002158619,0.00002808805,0.0001014076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004693327,"threshold_uncertainty_score":0.6025339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1500375925529179,"score_gpt":0.3662420308368275,"score_spread":0.2162044382839096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}